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KEPPRA TOXICITY
Tue, 04/24/2007 - 21:19Topic: Medication Issues
A week ago yesterday, April 16th, my daughter started having symptoms of a toxic level to Keppra, the anti-seizure medication she was taking. She said she had been very tired for a couple of weeks. Her dose was 1000mg twide daily. She said she felt lightheaded & dizzy. She said she was having trouble processing information---like she was "high". That next morning she had a Keppra level drawn. Keppra was decreasd to 500 twice daily. By the next day she was having trouble speaking: slurred speech, speech arrest & stuttering with unsteady gait. At that point she went to the ER. She had a CT of her brain which was normal. She was admitted to the hosp. She had an EEG which was abnormal. She had a MRI of the Brain & an MRA, both which were normal. On 4-20 Keppra came back > 150. (Normal is 20-30). Last Keppra level was 3-24-07 & it was 48. The doctors there have never seen a Keppra level this high. Is it possible to network & see how long it will take the Keppra to leave her body? She has to walk with a walker. Her legs are too weak to support her without the walker. Her speech remains impaired with speech arrest & stuttering, plus it is very slow. ANYONE EVER HEARD OF SUCH A HIGH LEVEL??? Any treatment???
Comments
I was taking 1500 twice a day
Submitted by annettemk4@yahoo.com on Fri, 2019-04-12 - 14:29
I was taking 1500 twice a day along with zonisamide 150 mg twice a day. Then I was reduced to 1000mg in the morning with no other changes. Then I received a letter from my neurologist stating he was is not going to practice medicine any longer. It took me a long about 3 months to find the doctor that I am going to now.
I just had this same
Submitted by Ayanna22 on Tue, 2018-12-18 - 12:42
I just had this same discussion with my dr as we speak. She says there are no toxic levels, everytime i turn around she wanta to up dose. They had me on 1500 2x daily. My other nueroligist dropped it to 750 3x daily. And my epilepsy dr was pissed. I said according to him u guys have me taking too much
I had a problem with generic
Submitted by Kristi Nelson on Sat, 2020-05-16 - 07:42
I had a problem with generic Dilantin. Suddenly I had such a heavy head I couldn't sit up an hour after I took my medications. I felt burning sensation in my skin each night. So I saw my primary doctor and she found my Dilantin blood level was 47. It's supposed to be around 15. It has been harder to talk. We changed to the brand Dilantin and then my blood level bananced. But I still feel burning skin each day and night. Especially at bedtime. I also take 4000 mg of Keppra (generic), 300 mg of Lyrica (generic).