Drug Interactions

Yes. Most seizure medicines (also known as antiepileptic drugs or AEDs) interact with each other and with other medicines. Such interactions are common and can be dangerous. The effects of interactions between two medications vary. Some seizure medicines can lower or raise the levels of other types of medicines in your blood. Some combinations cause the levels of both medications to fall, some cause one level to fall and one level to rise, and some cause unpredictable effects.

If you've been taking the same combination of medicines for a long time and are doing well, you probably don't need to be too concerned. But if you are just starting one of the medicines or are having problems, check with your doctor.

Make sure you are under the care of a doctor who knows about all the medications you are taking. Also, tell your pharmacist or doctor about all over-the-counter medications you use, including herbs and dietary supplements, because some of them can affect seizure medicine levels, cause seizures in someone who has never had a seizure, or increase seizure frequency in a person with epilepsy.

Most women with epilepsy can take birth control pills without affecting seizure control. Although there is usually no change when the pills are started, some women have slightly improved seizure control and some have a slight worsening.

Some seizure medicines reduce the effectiveness of birth control pills by increasing the breakdown, or metabolism, of estrogen and progesterone by the liver. This can increase the chance of getting pregnant while on the pill. If you are a sexually active woman taking birth control pills, ask your doctor if your seizure medicines will reduce the effectiveness of birth control pills. The best-known seizure medicines that interact in this way include: carbamazepine (Tegretol, Carbatrol), phenytoin (Dilantin, Phenytek), phenobarbital, primidone (Mysoline), oxcarbazepine (Trileptal), topiramate (Topamax), felbamate (Felbatol), and perampanel (Fycompa).

Reviewed By:

Joseph I. Sirven MD / Patricia O. Shafer

on Wednesday, March 19, 2014

Resources

Epilepsy Centers

Epilepsy centers provide you with a team of specialists to help you diagnose your epilepsy and explore treatment options.

Epilepsy Medication

Find in-depth information on anti-seizure medications so you know what to ask your doctor.

Epilepsy and Seizures 24/7 Helpline

Call our Epilepsy and Seizures 24/7 Helpline and talk with an epilepsy information specialist or submit a question online.

Tools & Forms

Download our seizure tracking app, print out seizure action plans, or explore other educational materials.