Specific Problems Affecting Infants


Babies born to mothers with epilepsy face a host of specific problems.

The risk for birth defects or malformations in children born to women with epilepsy is about twice that for the general population.  This means that birth defects generally occur in 4% to 6% of infants born to women with epilepsy. Studies are still being carried out, and there is still a lack of information on the newer seizure medications.

  • Information obtained from pregnancy registries so far do show that some seizure medications have higher risks than others. Valproic acid or valproate appears to have the greatest risk of major congenital malformations (10%). 
  • The most common type of  birth defects include cleft lip and palate and certain types of heart defects. Valproic acid has been associated with a 1-2 % risk of spina bifida (a serious malformation affecting the brain and spinal cord) in the infant. 

Some types of birth defects can be identified before delivery and help parents with family planning. 

  • An ultrasound done between 16 and 18 weeks of pregnancy can check for problems in the infant with an accuracy rate of over 95%.
  • Blood tests can measure a protein (called alpha fetoprotein) that is higher in the blood of a mother when the baby has a birth defect.
  • Amniocentesis is a test of the amniotic fluid that surrounds the baby in the uterus.

Developmental delay is when children tend to be less likely to learn quickly. The development of language skills in particular tends to be slower.  This condition affects 2% to 6% of births and differs from retardation in that children with developmental delay sometimes are not permanently impaired, although it's uncertain how many of them catch up. This may be seen more often in children whose mothers had poor seizure control, low intelligence scores or were taking valproic acid during pregnancy. 

About 2% of the children whose mothers have epilepsy will develop epilepsy. This rate is about double that of the general population.  Having a father with epilepsy does not seem to increase the risk.

Stillbirths or miscarriage are slightly more common in infants born to mothers with epilepsy, however the rate is still very low. For example, stillbirths or miscarriage occur in 1.7% of pregnancies, which is 2 to 3 times higher than in women without epilepsy. The reason for the greater rate of infant death is unclear, but it appears to be related to the mother's seizure control—the more uncontrolled the mother's seizures, the higher the infant mortality rate.

Bleeding once was a major problem in newborns of mothers with epilepsy, but it has been declining.  The condition is called neonatal internal hemorrhaging. 

  • While the effect of Vitamin K is not fully known, pregnant women with epilepsy who are taking enzyme-inducing medications (for example phenytoin, carbamazepine, phenobarbital, primidone) may be given 10 mg Vitamin K daily during the last four weeks before delivery to decrease the risk of this problem.
  • Newborns of mothers taking these seizure medications during pregnancy should be given Vitamin K 1 mg by injection at birth. (Note that this should be done for all babies born in the U. S.)

This problem is seen about twice as often in infants of mothers with epilepsy. The use of topiramate during  pregnancy has been associated with a low birth weight in 9.8% of children exposed to the drug before birth.

Authored By:

Steven C. Schachter MD

on Friday, February 04, 2022

Reviewed By:

Joseph I. Sirven MD
Kimford J. Meador MD
Patty Obsorne Shafer RN, MN

on Friday, March 07, 2014


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