2018 Research Roundtable for Epilepsy

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Evolving Concepts in Endpoints and Populations in Epilepsy Trials
Friday, June 1, 2018

The 2018 Research Roundtable for Epilepsy (RRE), held May 17-18, 2018, centered on the topic, “Evolving Concepts in Endpoints and Populations in Epilepsy Trials.” Twenty-five industry organizations, regulators (such as from the U.S. Food and Drug Administration and European Medicines Agency), and community organization representatives gathered for an in-depth discussion. The RRE was led by the following members of the organizing committee:

  • Dr. Kathleen Farrell, Director of Clinical Research, Epilepsy Foundation
  • Dr. Brandy Fureman, Vice President of Research and New Therapies, Epilepsy Foundation
  • Dr. Billy Dunn, Director, Division of Neurology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration
  • Dr. Jacqueline French, Chief Scientific Officer, Epilepsy Foundation and RRE Co-Chair
  • Dr. Nathan Fountain, professor of neurology and director of the F.E. Dreifuss Comprehensive Epilepsy Program at the University of Virginia and RRE Co-Chair

The RRE was guided by a panel of excellent speakers with expertise from:

  • Clinical care
  • Experiences as a person living with epilepsy
  • Research backgrounds

Meeting Goals

The goals of the meeting included:

  • Review of the current landscape of pediatric epilepsy clinical trials
  • Consider the reasoning for grouping vs. splitting populations by seizure type or by syndrome
  • Discuss the full spectrum of disease and how to assess epileptic conditions that comprise more than just seizures
  • Learn which co-occuring conditions are a priority to study from the perspective of both people with epilepsy and caregivers
  • Learn from the experiences of drug and device companies who have incorporated multiple outcomes into their epilepsy trials
  • Identify potential methodologies and statistical considerations for incorporating non-seizure domains into epilepsy studies going forward

Caregivers and leaders representing the Dravet Syndrome Foundation, the Lennox-Gastaut Syndrome Foundation, and the Tuberous Sclerosis Alliance highlighted the unmet need to look at:

  • Epilepsy-related conditions as a whole
  • Quality of life of the person living with epilepsy and the whole family
  • Developing therapies with the guidance of people with epilepsy and caregivers

What's Next?

  • Publication of the 2018 RRE meeting discussion is pending, with a goal of early 2019, in Neurology.
  • If interested in learning more, please contact Dr. Kathleen Farrell at kfarrell@efa.org.
Authored by: Kathleen Farrell on 6/2018
About the Research Roundtable for Epilepsy

The Research Roundtable for Epilepsy (RRE) is an initiative of the Epilepsy Foundation to help create new treatments and diagnostic tools for people with epilepsy by collectively addressing roadblocks to research and development.

Previous RRE topics include:

For additional information about the Research Roundtable for Epilepsy, please contact Dr. Kathleen Farrell at kfarrell@efa.org.

Our Mission

The mission of the Epilepsy Foundation is to lead the fight to overcome the challenges of living with epilepsy and to accelerate therapies to stop seizures, find cures, and save lives.

 
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