As a broad-spectrum antiepileptic drug, Depakote (divalproex sodium) can be effective against many types of seizures common in children. It has been used for many years to treat...

As a broad-spectrum antiepileptic drug, valproic acid can be effective against many types of seizures common in children. It has been used for many years to treat children with absence...

Carbamazepine is metabolized and eliminated by the liver. It is metabolized by the hepatic P450 system (in particular, the 3A4 isoenzyme). Carbamazepine is ~70-80% protein-bound. Carbamazepine...

Clonazepam is metabolized in the liver by the cytochrome P-450 system and the metabolites are excreted by the kidneys. Clonazepam is approximately 85% protein bound. Clonazepam...

Diastat is well absorbed following rectal administration and reaches peak plasma concentrations in 1.5 hours. The half-life in adults is approximately 46 hours. Diazepam and its...

Absorption The rate of absorption depends on the formulation. The most common form of phenytoin is brand-name Dilantin in 100-mg capsules called Kapseals....

Absorption Gabitril is quickly and almost completely absorbed. Oral bioavailability is approximately 90% and absorption is linear over the therapeutic dosage range. Maximum serum concentrations are attained within 45 to 90 minutes...

Klonopin is metabolized in the liver by the cytochrome P-450 system and the metabolites are excreted by the kidneys. Klonopin is approximately 85% protein bound. Klonopin...

Mysoline is metabolized in the liver to phenobarbital and another active compound, phenylethylmalonamide. It is metabolized by the hepatic P450 system. Mysoline is ~70-80% protein-bound. Mysoline is rapidly and nearly completely...

Phenobarbital is metabolized in the liver and renally excreted. Mysoline is ~45% protein-bound. Phenobarbital is rapidly and nearly completely absorbed following oral and intramuscular...