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Program
Day 1 | Day 2 | Day 3

On June 5-7, 2014 in San Francisco, CA, the Epilepsy Therapy Project, an initiative of the Epilepsy Foundation presented the 4th Biennial Epilepsy Pipeline Conference 2014, held at the Hyatt Regency, San Francisco.

Showcasing the most promising epilepsy therapies from healthcare companies dedicated to pioneering and advancing drugs, biologics, technologies and devices for epilepsy and seizures, this year's conference featured the third annual "Shark Tank" competition, in addition to a day designated for people with epilepsy, families and advocates. The conference brought together decision-makers with a stake in the field of epilepsy treatment, therapeutic innovation and product development. Speakers and attendees included emerging biotech and medical technology companies, major pharmaceutical and device companies, and researchers and innovators at the cutting-edge of epilepsy and CNS treatment advances.

Read the press release for more information


LIVE STREAMING INFORMATION

To meet the demand and make this program accessible to as many people as possible, all 3 days were streamed live via the Epilepsy Foundation's YouTube account.


PIPELINE CONFERENCE APPS

Get it on Google Play   Available on the iPhone App Store


With Thanks to Our Supporters:

New Therapy Innovators

Sunovion
Eisai

 


New Therapy Discovery Circle

UCB - The Epilepsy Company

 


New Therapy Catalysts

Danny Did Foundation
Medtronic
Questcor
Visualase
Openconcept
Upsher Smith
Cyberonics

 



Epilepsy Pipeline Conference 2014 - Agenda

Day 1 - Thursday June 5, 2014

7:00-8:00 Registration and Continental Breakfast

SESSION I: Introduction and Keynote Addresses
Chair: Philip Gattone, CEO and President, Epilepsy Foundation
8:00-8:15 Welcome and Overview Warren Lammert, Chairman, Epilepsy Foundation

Jacqueline French, MD, Professor of Neurology, New York University, Co-director Epilepsy Research and Epilepsy Clinical Trials, NYU Comprehensive Epilepsy Center
2013 Epilepsy Pipeline Scorecard: Pipeline Advances and Challenges
8:15-8:30
Keynote: Annual State of the Drug Pipeline Jacqueline French, MD; Professor of Neurology, New York University
8:30-8:45
Keynote: Annual State of the Device Pipeline Robert Fisher, MD, PhD, Maslah Saul MD, Professor of Neurology, Director Stanford Comprehensive Epilepsy Program

SESSION II: What was better in 2013 than 2012--Progress in Epilepsy Therapy

Chair: Jacqueline French, MD, Professor of Neurology, New York University
8:45-9:15
FDA and epilepsy trials: Past, Present and Future
Russell Katz, MD, Consultant, Epilepsy Study Consortium
9:15-9:30
Why Industry Should Keep Investing in Epilepsy
Christopher Gallen, MD, PhD, President and CEO, SK Biopharmaceuticals | SK Life Sciences
9:30-10:00
The NINDS ASP: Yesterday, Today and Tomorrow
John Kehne, PhD, Program Director, National Institute of Health, National Institute of Neurological Disorders and Stroke

H. Steve White, PhD, Professor and Director, Anticonvulsant Drug Development Program, University of Utah
10:00-10:10
Epilepsy Therapies: Accomplishments and Challenges
Roger J. Porter, MD, CSO, Epilepsy Foundation
10:10-10:25
Networking Break (15 minutes)

SESSION III: Early-Stage Drug Pipeline: Proof of Principle through IND

Chair: Roger J. Porter, MD, Chief Scientific Officer, Epilepsy Foundation
10:25-10:35 Intellimedix | Platform of computational, in-Silico screening, and then hi-thru put testing in zebra fish with an initial focus on Dravet but broad focus on Epilepsy Jeffrey Skolnick, PhD, Scientific Advisor, Intellimedix, Director of the Integrated Biosystems Institute at Georgia Institute of Technology
10:35-10:45
Asklepios BioPharmaceutical, Inc. | Galanin gene delivery for temporal lobe epilepsy Cynthia Rask, MD, CMO, Asklepios BioPharmaceutical, Inc.
10:45-10:55 AurimMed Pharma, Inc. | AMP-X-0079 Amir Pesyan, Chairman and CEO, AurimMed Pharma, Inc.
10:55-11:05 BioCrea | LT GABA PAMS for refractory epilepsy Norbert Hoefgen, PhD, VP Discovery, BioCrea
11:05-11:15
EpaleX | Inhaled Treatment for Refractory Epilepsy Michael A. Rogawski, MD, PhD, Professor, Department of Neurology, University of California, Davis
11:15-11:25 Fluorinov Pharma Inc. | FV-082: A Safer Orally Active Broad Spectrum Anti-Epileptic Drug Candidate Malik Slassi, PhD, President and CSO, Fluorinov Pharma Inc.
11:25-11:35 NeuroGate Therapeutics, Inc. | Extended NeuroAmides Harold Kohn, PhD, Kenan Distinguished Professor, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy and Department of Chemistry University of North Carolina – Chapel Hill, and Founder, NeuroGate Therapeutics, Inc.
11:35-11:45
NeuroGenomeX, Inc. | 2DG Thomas P. Sutula, MD, PhD, Founder, CTO and Director, NeuroGenomeX, Inc.
11:45-11:55
INSYS Therapeutics, Inc. | Synthetic CBD
Mark Davis, Senior Director Clinical
11:55-12:05
NeuroAdjuvants, Inc. | Galanin Receptor 2-Based Therapy
H. Steve White, PhD, Professor and Director, Anticonvulsant Drug Development Program, University of Utah
12:05-12:15 University of South Florida | Ketogenic Compounds for the Treatment of Epilepsy
Dominic D'Agostino, PhD, Assistant Professor, Hyperbaric Biomedical Research Laboratory
12:15-12:25 SciFluor Life Sciences LLC | KCNQ2/3
D. Scott Edwards, Vice President and General Manager
12:25-12:35
Sage Therapeutics | Development of Programs for Status Epilepticus
Jeffrey Jonas, MD, CEO, Sage Therapeutics
12:35-2:10 Networking Lunch and Poster Session (1 hour, 30 minutes)

SESSION IV: Early-Stage Diagnostic Devices and Product Pipeline: New Concepts and Initial Findings
Chair: Daniel Friedman, MD, Assistant Professor of Neurology, New York University
2:10-2:20 Cyberonics | ProGuardian RestTM | An innovative, in-home device systems designed to monitor, detect, and log night-time seizure activity Laurie Groven, Global Medical Device / Diagnostic Marketing and Sales Executive, Cyberonics
2:20-2:30 Brain Sentinel | EMG Based Convulsive Seizure Detection and Warning System Jose E. Cavazos, MD, PhD, VP, Medical Affairs, Brain Sentinel, LGCH, Inc.
2:30-2:40 Epitel, Inc. | Wireless EEG Patch Mark Lehmkuhle, PhD, CEO, CTO, Epitel, Inc.
2:40-2:50 Empatica | Embrace: Autonomic and Seizure Events – Personalized Monitoring and Alerts Rosalind W. Picard, Sc.D., Empatica, Inc. and MIT Media Lab
2:50-3:00 Smart Monitor | Automated Seizure Tracking and Recording Anoo Nathan, CEO, Smart Monitor
3:00-3:10 RTI International | ESAP
Kristin H. Gilchrist, PhD, Research Scientist Electronics and Applied Physics Division, RTI International
3:10-3:30

Panel Session

Seizure detection and alerting devices:  Are they ready for prime time? 
In this panel discussion, we will discuss the role that non-invasive seizure detection device may play in the management of epilepsy and seizure safety. Our panelists will discuss the benefits of various detection methods and form factors for different patient populations. We will discuss which type of seizures are a priority for detection and whether understanding seizure-related physiologic changes could provide additional valuable information. We will also address various alerting methods and optimal performance characteristics of these devices for different applications.

  • Tom Stanton, Executive Director, Danny Did Foundation
  • Michelle Welborn, PharmD, President, Intractable Childhood Epilepsy Alliance
  • Catherine Jacobson, PhD, Post-doctoral Fellow, Pediatric Epilepsy, University of California, San Francisco
Moderator: Daniel Friedman, MD
Assistant Professor of Neurology, NYU, Comprehensive Epilepsy Center
3:30-3:45 Networking Break (15 minutes)

SESSION V: Late-Stage and Approved Devices--What is New?
Chair: Daniel Friedman, MD, Assistant Professor of Neurology, New York University
3:45-3:55 Medtronic, Inc. | DBS Therapy for Epilepsy Jon Giftakis, PhD, Senior Principal Scientist, Medtronic Neuromodulation
3:55-4:05 NeuroSigma, Inc. | eTNS Christopher DeGiorgio, MD, Professor of Neurology, UCLA
4:05-4:15 UCLA | Ultrasound for seizure modulation John Stern, MD, Director, Epilepsy Clinical Program, UCLA Department of Neurology, Co-Director, UCLA Seizure Disorder Center
4:15-4:25 Visualase, Inc. | Laser ablation in neurosurgery Ashok Gowda, PhD, Founder and Chief Operating Officer
4:25-4:35 Swedish Neuroscience Institute | MR-guided focused ultrasound for treatment of mesial TLE
John Snell, PhD, Technical Director-Brain Program, Focused Ultrasound Foundation
4:35-4:45 Boston Children's Hospital | TMS
Alexander Rotenberg, PhD, MD, Director, Neuromodulation Program, Associate Professor of Neurology, Boston Children's Hospital, Harvard Medical School

SESSION VI: Nonprofit Organization, Government and Crowdfunding--Grants, Awards and Funding to Advance Research to the Next Critical Stage

Chair: Roger J. Porter, MD, Chief Scientific Officer, Epilepsy Foundation
4:45-5:45 Presentations and Panel Discussion
  • Jan Buelow, PhD, Vice President Programs and Research, Epilepsy Foundation
  • Rajesh Ranganathan, PhD, Director, Office of Translational Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health | Blueprint Program
  • H. Steve White, PhD, Research Director, Citizen's United for Research in Epilepsy (CURE), Professor and Director, Anticonvulsant Drug Development Program, University of Utah
  • Bre DiGiammarino, Cause Director, Indiegogo | Crowdfunding – n. & v. The pooling of small contributions of funds from a group of people for the purpose of making something larger happen
Moderator:
Roger J. Porter, MD
, Chief Scientific Officer, Epilepsy Foundation
5:45-6:00

Lifetime Accelerator Award: Honoring H. Steve White, PhD!

6:00-7:30

Networking Reception and Lifetime Accelerator Award Celebration

Day 2 - Friday June 6, 2014

7:00- 8:00 Networking Continental Breakfast


SESSION VII: New Directions and Opportunities in Epilepsy Research

Chair: Jacqueline French, MD, Professor of Neurology, New York University

8:00- 8:30 New Directions in Epilepsy Research Daniel Lowenstein, MD, Robert B. and Ellinor Aird Professor and Vice-Chair of Neurology, Director, UCSF Epilepsy Center, University of California, San Francisco
8:30-8:45 Improving Delivery of Therapies in People Who Need Them: An Industry Perspective Mark Evenstad, CEO, Upsher-Smith
8:45- 9:45 The Role of Corporate and Government Partnerships in Developing New Epilepsy Products | Presentations and Panel Discussion
Moderator: Roger J. Porter, MD
  What Does Big Pharma Look for in a New Drug for Epilepsy?
Santiago Arroyo, MD, PhD, VP, Head of Clinical Research & CMO, Pharmatherapeutics, Worldwide Research & Development, Pfizer Inc.
  What Does Big Pharma Look for in a New Drug for Epilepsy?
Roy E. Twyman, MD, Vice President and Global Head of CNS Development, Janssen Pharmaceuticals R&D
  What Does Medium Sized Epilepsy-Oriented Pharma Look for in a New Drug for Epilepsy?
Michael Gold, MD, Vice-President and Head of the CNS Practice, UCB
  What Does the Device Industry Look for When Considering Developing a New Product in the Epilepsy Space? Frank Fischer, CEO, NeuroPace, Inc.
  Panel Discussion and Q&A  
9:45-9:55 Drug Development Transition Issues Rajesh Ranganathan, PhD, Director, Office of Translational Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health
9:55-10:20 Networking Break (25 minutes)


SESSION VIII: Clinical Stage Drugs

Chair: Steven C. Schachter, MD, Professor of Neurology, Harvard Medical School, Chief Academic Officer, Consortia for Improving Medicine with Innovation and Technology

10:20-10:30 Ultragenyx Pharmaceutical Inc. | UX007G Emil D. Kakkis, MD, PhD, CEO, Ultragenyx Pharmaceutical Inc.
10:30-10:40 Alexza Pharmaceuticals | Inhaled Alprazolam
James V. Cassella, PhD, CSO and Executive Vice President, R&D, Alexza Pharmaceuticals, Inc.
10:40-10:50 GW Pharmaceuticals | Epidiolex in Pediatric Epilepsy
Alice Mead, JD, Vice President, Professional Relations
10:50-11:00

Insero Health | Huperzine Update

Stephen D. Collins, MD, PhD, President and CEO, Insero Health, Inc.
11:00-11:10
Marinus Pharmaceuticals, Inc. | Ganaxolone
Gail M. Farfel, PhD, Chief Clinical Development and Regulatory Officer, Marinus Pharmaceuticals, Inc.
11:10-11:20
SK LifeScience, Inc. | YKP 3089
Christopher Gallen, MD, PhD, President and CEO, SK Biopharmaceuticals | SK Life Sciences
11:20-11:30
UCB | Brivaracetam Update
Joseph D'Souza, Senior Global Medical Director, UCB
11:30-11:40
Vertex Pharmaceuticals | VX-765
Jacqueline French, MD, Professor of Neurology, New York University, Co-Director Epilepsy Research and Epilepsy Clinical Trials, NYU Comprehensive Epilepsy Center
11:40-11:50
Sapienza University, University of Utrecht | Pitolisant, a histamine 3 receptor antagonist, in the human photosensitivity model Dorothee Kasteleijn- Nolst Trenité, Prof Neuroscience at Sapienza University, Rome, Italy, Sr. Researcher Medical Genetics, University of Utrecht, The Netherlands
11:50-12:00 IzumiBiosciences, LLC |  Elacridar

Ton Bunt, MD MBA, President, CEO & Founder, IzumiBiosciences, LLC

12:00-12:10 Brabant Pharma | 22 Years of Clinical Data using Low-dose Fenfluramine to Treat Dravet Syndrome Rick Stewart, Director, Brabant Pharma
12:10-12:20 Realm of Caring Foundation | Charlotte's Web: The Facts and the Future Paige Figi, Spokesperson and Co-Founder
12:20-1:50 Networking Lunch and Poster Session (1 Hour, 30 Min.)


SESSION IX: Who is Investing in Epilepsy and CNS Therapy Research and Innovation Today? Funding Beyond Angels, Grants and Awards

Chair: Warren Lammert, Chairman, Epilepsy Foundation

1:50-2:50 Panelists:
  • Greg Simon, CEO, Poliwogg
  • Manuel O. Lopez-Figueroa, PhD, Vice President, Bay City Capital, Scientific Liason, Pritzker Neuropsychiatric Disorders Research Consortium
  • Sigrid Van Bladel, PhD, Venture Partner, Aberdare Ventures
Moderator: Casey Lynch
Managing Director, NeuroInsights, LLC, Neurotechnology Industry Organization (NIO), CEO, Cortexyme, Inc.


SESSION X: Shark Tank Competition

Chair: Joseph I. Sirven, MD, Chair of Neurology at Mayo Clinic in Arizona and Editor-in-Chief of epilepsy.com

2:50-3:00

Update: 2012 Shark Tank Winner | SAMi

Charles Anderson, HiPass Design LTD

3:00-3:10
Update: 2013 Shark Tank Winner | AED Drug Levels On A Chip Utkan Demirci, MS, PhD, Bio-Acoustic MEMS in Medicine Labs, Brigham and Women's Hospital, Harvard Medical School, Harvard-MIT Health Sciences and Technology
3:10-4:50 Shark Tank Moderator: Jacqueline French, MD
 
  2014 Sharks:

Jim Abrahams, Founder, Executive Director, The Charlie Foundation

Ari Mackler, PhD MBA, Vice President, Clinical Development, POM Wonderful | Paramount Farms | Paramount Citrus

Martha Morrell, MD, Clinical Professor, Neurology & Neurological Sciences, Stanford School of Medicine

Andrew Smith, Healthcare Investment Banking Analyst, Credit Suisse

Elson So, MD, President, American Epilepsy Society, Professor of Neurology, Mayo Clinic

 
  Shark Tank Finalists:  
  Shower Power – Bathing Safety Monitoring System Jon Davis, Inventor
  Mc10 'Biostamp' Wearable Sensors: Wireless Convulsion and Seizure Sensing for Epilepsy Patients Nirav Sheth, Head of Medical Market Development, Mc10, Inc.
  WebEase – Y: Enhance Youth Epilepsy Management Behaviors Sandra L. Helmers, MD, MPH, Professor of Neurology and Pediatrics, Emory University School of Medicine
  An in-home and inexpensive anti-epileptic drug monitoring device using saliva Oren Knopfmacher, PhD, Avails Medical, Inc.
  Using Smartphones to Detect Seizures (Seizario app) Ahmed Helmy, Associate Professor, Computer and Information Science and Engineering (CISE) Department, University of Florida

Amir Helmy, Co-Designer and Developer, Seizario App
  Ketonix Breath Ketone Analyzer Michel Lundell, M Object Oriented Software Engineering AB
4:50-5:00
Closing Remarks
Philip Gattone, President and CEO, Epilepsy Foundation
5:00-6:30 Light Networking Reception

FAMILY DAY: Day 3 - Draft

Epilepsy: Overcoming the Challenges of Today & Accelerating Toward Tomorrow
Saturday June 7, 2014
8:00-8:30 Registration
8:30-8:40 Introductions/Overview

Patricia Osborne Shafer, RN, MN Associate Editor and Community Manager, Epilepsy Foundation: Beth Israel Deaconess Medical Center

8:40-9:00 Challenges of Epilepsy Elson So, MD, Mayo Clinic, President, American Epilepsy Society
9:00-9:15 Through Our Eyes Patricia Barnes, Artist and Epilepsy Advocate

Krystina Bertoldi,
Epilepsy Advocate, San Francisco, CA
9:15-9:45 The Epilepsy Pipeline 2014
Warren Lammert, Chairman, Epilepsy Foundation
  New Drugs: How to Make One and What's Coming Roger J. Porter, MD, Chief Scientific Officer, Epilepsy Foundation
9:45-10:00 Break
10:00-10:20 What's New in Seizure Medications Jacqueline French, MD, Professor of Neurology, New York University, Co-director Epilepsy Research and Epilepsy Clinical Trials, NYU Comprehensive Epilepsy Center
10:20-10:40 Rescue Therapies James Cloyd, PharmD, Director, Center for Orphan Drug Research; Professor, College of Pharmacy, University of Minnesota
10:40-11:05 Medical Marijuana Derek Chong, MD, MSc, Assistant Professor of Neurology, NYU Medical Center

Elizabeth Aquino, Writer, Family Advocate
11:05-11:25
Moving New Therapies into Practice Joseph Sirven, MD, Chair, Department of Neurology, Mayo Clinic Arizona; Editor-in-Chief, Epilepsy.com

Maureen Sheehan, CPNP, Child Neurology, Packard Children's Hospital at Stanford

11:25-11:55

Panel: Q and A

  • Jacqueline French, MD
  • James Cloyd, PharmD
  • Derek Chong, MD, MSc
  • Elizabeth Aquino
  • Maureen Sheehan, CPNP
Moderator: Joseph Sirven, MD, Chair, Department of Neurology, Mayo Clinic Arizona; Editor-in-Chief, Epilepsy.com
12:00-1:00 Lunch/Exhibits  
  Presentation - Patient Engagement in Research Brandy E. Fureman, PhD, Program Director, National Institutes of Neurological Diseases and Stroke, National Institute of Health

Janice Buelow RN, PhD, Vice-President, Programs and Research, Epilepsy Foundation
1:00-1:10 The Personal Perspective Lisa Moss, Director, Donor Relations, Tuberous Sclerosis Alliance
1:10-1:30 When Seizures Don't Respond to Medications
Paul Garcia, MD, Professor of Clinical Neurology, Director, Clinical Epilepsy Services, University of California San Francisco
1:30-1:50 New Approaches to Surgery Kurtis Auguste, MD, Assistant Professor of Pediatric Neurosurgery, University of California San Francisco
1:50-2:15 Devices for Epilepsy
Robert Fisher MD, PhD, Maslah Saul MD Professor of Neurology & Neurological Sciences, Director, Comprehensive Epilepsy Center, Stanford University School of Medicine
2:15-2:45

Panel Q and A

  • Paul Garcia, MD
  • Kurtis Auguste, MD
  • Robert Fisher, MD, PhD
  • Lisa Moss
  • Krystina Bertoldi
Moderator: Patricia Dean, ARNP, MSN, Clinical Coordinator, Pediatric Nurse Practitioner, Miami Children's Hospital Brain Institute
2:45-3:00 Break
3:00-3:25
Dietary Therapies Beth Zupec-Kania, RDN, CD, Consultant Nutritionist/Dietician, Ketogenic Therapies LLC
3:25-3:50
Exercise and Epilepsy: Does it Work or Not? Alison Pack, MD, Associate Professor of Clinical Neurology, Columbia University Medical Center
3:50-4:00

The Personal Perspective

Chanda Gunn, Athletes vs. Epilepsy
4:00-4:20

Panel Q and A

  • Beth Zupec-Kania, RDN, CD
  • Alison Pack, MD
  • Chanda Gunn
Moderator: Patricia Osborne Shafer, RN, MN, Associate Editor and Community Manager, Epilepsy Foundation: Beth Israel Deaconess Medical Center
4:20-4:30

Wrap Up - Through Our Eyes

Logan Welborn
4:30-5:00
Ice Cream Social