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KEPPRA TOXICITY

Tue, 04/24/2007 - 21:19
Topic: Medication Issues
A week ago yesterday, April 16th, my daughter started having symptoms of a toxic level to Keppra, the anti-seizure medication she was taking. She said she had been very tired for a couple of weeks. Her dose was 1000mg twide daily. She said she felt lightheaded & dizzy. She said she was having trouble processing information---like she was "high". That next morning she had a Keppra level drawn. Keppra was decreasd to 500 twice daily. By the next day she was having trouble speaking: slurred speech, speech arrest & stuttering with unsteady gait. At that point she went to the ER. She had a CT of her brain which was normal. She was admitted to the hosp. She had an EEG which was abnormal. She had a MRI of the Brain & an MRA, both which were normal. On 4-20 Keppra came back > 150. (Normal is 20-30). Last Keppra level was 3-24-07 & it was 48. The doctors there have never seen a Keppra level this high. Is it possible to network & see how long it will take the Keppra to leave her body? She has to walk with a walker. Her legs are too weak to support her without the walker. Her speech remains impaired with speech arrest & stuttering, plus it is very slow. ANYONE EVER HEARD OF SUCH A HIGH LEVEL??? Any treatment???

Comments

Was just reading your post as

Submitted by taravc on Sun, 2018-06-03 - 01:51
Was just reading your post as I was finding info about peppa as my son is on this. I was told my seizures I have as well are anxiety related so you are not alone but I as well don't know much about it as it was never really explained to me.

Re: KEPPRA TOXICITY

Submitted by Bazilia on Fri, 2012-04-06 - 16:58
Im 36 and had to begin taking keppra after a brain tumor and this drug 1000mg 2x a day made me forget everything, stutter like never before, made my mobility worse. It was the scariest thing to feel like youve lost your mind. I just stopped taking it 2 days ago and my heart feels lik its racing, i have a ton of head pressure even after surgery, and im suddenly OCD, a grain of sugar on the counter drives me nuts, the doors all have to be closed, nothing on tables. Dr said this will stop in a week+ good luck and god bless us

Re: KEPPRA TOXICITY

Submitted by Loulou13 on Tue, 2012-05-15 - 12:22

Hi,  My son, only 8, has been on Keppra 1150mg twice daily for about 6 months, total 8 months while titrating.

After the 1st month with dosage of 700-950mg twice daily, he began having slowed speech, spaciness, behavior issues, slow reading, hesitating, interupted speech with hum, hum in between words.  Our doctor didn't believe it was from medication and sent us to a psychiatrist (no, we didn't go...........actually the neurologist needed the psychiatrist).  Our new neuro is weaning us off (one month down and one month to go).  No improvement in speech

and that scares me.  We've never had dysfluent speech.  Can you please tell me how long before your symptoms improved..................  I'm worried about this, as if the seizures aren't enough!!

 Please let me know.

 Worried mom.

Hi,  My son, only 8, has been on Keppra 1150mg twice daily for about 6 months, total 8 months while titrating.

After the 1st month with dosage of 700-950mg twice daily, he began having slowed speech, spaciness, behavior issues, slow reading, hesitating, interupted speech with hum, hum in between words.  Our doctor didn't believe it was from medication and sent us to a psychiatrist (no, we didn't go...........actually the neurologist needed the psychiatrist).  Our new neuro is weaning us off (one month down and one month to go).  No improvement in speech

and that scares me.  We've never had dysfluent speech.  Can you please tell me how long before your symptoms improved..................  I'm worried about this, as if the seizures aren't enough!!

 Please let me know.

 Worried mom.

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