The Research and Training Fellowships for Clinicians is for clinically trained professionals. This fellowship is one-year of supervised study and research. Individuals with an MD or DO who will have completed residency training in neurology, neurosurgery, pediatrics, internal medicine, or psychiatry by the time the fellowship commences may apply. Other clinically trained professionals (i.e. PharmD, Doctor of Nursing) are also eligible to apply.

Research and Training Fellowships for Clinicians provide one-year of supervised study and research for clinically-trained professionals with an M.D. or D.O. who have completed a residency in neurology, neurosurgery, pediatrics, internal medicine, or psychiatry. Other clinically trained professionals (i.e. PharmD, Doctor of Nursing) are also eligible. Grants awarded this cycle will help researchers study:

  • Automatic intraoperative mapping of epileptic networks;
  • Ictal cores, penumbras, and high frequency oscillations.

Automatic intraoperative mapping of epileptic networks

Mesha Gay Brown, M.D.
Resident
The Trustees of the University of Pennsylvania
Philadelphia, PA, United States

Less than 50% of patients with nonlesional extratemporal epilepsy achieve seizure freedom after epilepsy surgery. It has recently been discovered that high frequency oscillations (HFOs) within the brain may be biomarkers of epileptic networks. In order to test whether resecting HFO-generating brain regions improves outcome from epilepsy surgery it is vital that intracranial electrodes be placed so as to capture major HFO-generating regions. The goal of this proposal is to develop methods to map and localize interictal HFOs effectively, both intraoperatively and during video-EEG monitoring with intracranial electrodes, so as to define HFO-generating regions and minimize sampling error during electrode placement. These methods will be used in a preliminary study to determine if supplementary electrodes placed intraoperatively, based upon real-time HFO detection may more accurately localize epileptic networks during continuous inpatient recording outside of the operating room, and have the potential to improve outcome from epilepsy surgery.

Ictal cores, penumbras, and high frequency oscillations

Robert Connors
Fellow in Clinical Neurophysiology
Columbia University Medical Center
New York, NY, United States

This grant proposes a new interpretation of high-frequency electrical signals generated during an epileptic seizure and examines their relationship with a patient's clinical symptoms. Our work will help to localize the part of the brain generating seizures more precisely and will one day lead to more precise therapies for partial epilepsy.

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