Levetiracetam XR


Keppra XR is a different form of the same medicine. The "XR" stands for "extended-release," which means that the time it takes the pills to dissolve and release the medicine is longer. Most people need to take regular Keppra two or sometimes more times a day. It can be hard to remember to take pills that often. Keppra XR is designed so that the pills can be taken only once a day. So it's a lot easier to remember and more convenient.

Keppra XR is sold in the United States by UCB Pharma, Inc. The name or appearance may be different in various countries, but the dose (measured in milligrams, abbreviated "mg") usually will be the same. This description applies to the U.S. version:

Keppra (KEP-ruh) is the brand name used in the United States, Canada, the UK, Australia, and some other countries for the seizure medicine levetiracetam (lev-eh-teer-ASS-eh-tam).

Please see package insert.


Updated: 17/10/2023

Brand Name(s)

Keppra XR

Used to Treat

Focal Impaired Awareness or Complex Partial Seizures
Focal Aware Onset Seizure


Keppra-XR 500mg

(white, film-coated tablet, imprinted with "UCB 500XR" in red on one side)

Keppra-XR 750mg

(white, film-coated tablet, imprinted with "UCB 750XR" in red on one side)

Keppra XR is not available in generic (non-brand name) form.

Package Insert

Frequently Asked Questions

    How to take and store Levetiracetam XR?

    Follow your doctor's directions. Call if you have any questions. Treatment will usually be started with 1000 mg once a day.

    Keppra XR tablets must be swallowed whole. They should not be chewed, broken, or crushed.

    It's OK to take Keppra XR either with food or without food, but it's a good idea to take it the same way every time.

    Don't take more than the doctor prescribes. If you think you've taken extra tablets, call your doctor for advice. For a larger overdose, call your local poison control center or emergency room right away, unless you have special instructions from the doctor.

    Don't stop taking Keppra XR or change the amount you use without talking to the doctor first. Stopping any seizure medicine all at once can cause serious problems.

    Keppra XR should be stored at room temperature, away from light and humidity. (Don't keep the pills in the bathroom if it's damp there.) Of course, keep all Keppra XR out of the reach of children.

    What if I forget?

    If you forget a dose of Keppra XR, take it as soon as you remember if it's only been a few hours. If you're not sure about what to do, call the doctor's office for more advice.

    Do your best to follow the doctor's directions. If you forget doses often, it may be a good idea to get a special pillbox or watch with an alarm to remind you.

    Taking the right amount of seizure medicine on time every single day is the most important step in preventing seizures!

    How does Levetiracetam XR affect the brain?

    Brain cells need to work (fire) at a certain rate to function normally. During a seizure, brain cells are forced to work much more rapidly than normal. How Keppra XR helps prevent brain cells from working as fast as a seizure requires is still being investigated. It appears to work differently from other seizure medicines.

    How does the body digest Levetiracetam XR?

    After medicine is swallowed, it must be absorbed into the blood so it can move throughout the body. The process of absorbing, digesting, and excreting a medicine or food is called metabolism. The way the body metabolizes a particular medicine affects how often it must be taken. It also determines whether it will interact with other medicines or be affected by liver disease or kidney disease.

    Keppra XR is not metabolized by the liver. It also does not affect the way the liver metabolizes other medicines.

    Instead, the body eliminates Keppra XR through the kidneys. People with poor kidney function usually need to take less Keppra XR and they may take it less often, because it stays in their body longer.

    How well does the Levetiracetam XR work?

    Doctors have studied large numbers of patients to find out how well regular Keppra controls seizures. In most of the studies, the Keppra was given to people who were taking another seizure medicine but still having seizures. With Keppra, between 20% and 40% of these people had the number of seizures cut at least in half. They also didn't have much trouble with side effects.

    Keppra XR is not a perfect add-on seizure medicine for everyone, however. Sometimes people must try a series of combinations before finding what is best for them. But because Keppra XR doesn't interact with other medicines, it can be used as an add-on without the need for complicated changes in dosage.

    At least one study has found that Keppra also may be effective when used alone to treat partial seizures.

    What are the most common side effects of Levetiracetam XR?

    Keppra XR appears to be very safe.

    Some side effects that have been reported include:

    • sleepiness
    • loss of strength and energy
    • dizziness
    • anxiety
    • nervousness
    • irritability
    • depression
    • other mood changes

    Some of these are more likely during the first month of treatment.

    If you notice any of these problems, call the doctor's office. Sometimes the doctor can help by changing the amount of Keppra XR you take or how you take it. Don't stop taking Keppra XR or change the amount you take without the doctor's guidance.

    If you have just started taking Keppra XR (or have just started taking a larger amount), be careful doing anything that might be dangerous until you know whether you are feeling sleepy, dizzy, or uncoordinated.

    Allergic reactions
    There are no known allergic reactions to Keppra XR.

    Long-term side effects
    The long-term side effects of Keppra XR are not yet known.

    What are the most serious side effects of Levetiracetam XR?

    Very few people have serious reactions to Keppra XR. If you take it, you should be aware of them, however, so you and your family can recognize them.

    If you notice any of these symptoms, call your doctor right away:

    • decreased ability to cope with daily life events
    • depression
    • thoughts of suicide
    • severe anxiety, agitation, or confused thought

    It is important to remember that only a tiny number of people who take Keppra XR have any serious problems.

    On July 10, 2008, an advisory panel was convened by the Food and Drug Administration (FDA) to review data that the FDA had previously collected from drug studies showing an association between many of the antiepileptic drugs (AEDs) and suicidal ideation and behavior, which together are called suicidality. According to the FDA’s Alert, among the patients with epilepsy in these drug studies, 1 out of 1000 people taking the placebo (inactive substance) showed suicidality compared to approximately 3.5 out of 1000 people who took an AED. The FDA advisory panel voted to accept the FDA's data at its meeting on July 10.

    • Taking antiepileptic medicines may increase the risk of having suicidal thoughts or actions;
    • Do not make any changes to the medication regimen without first talking with the responsible healthcare professional;
    • Pay close attention to any day-to-day changes in mood, behavior and actions. These changes can happen very quickly so it is important to be mindful of any sudden differences.
    • Be aware of common warning signs that might be a signal for risk of suicide. Some of these are:
      • Talking or thinking about wanting to hurt yourself or end your life
      • Withdrawing from friends and family
      • Becoming depressed or having your depression get worse
      • Becoming preoccupied with death and dying
      • Giving away prized possessions

    We again urge patients and families to contact their doctor before stopping an epilepsy medication because this may possibly lead to seizures and worsening of mood.

    What else is Levetiracetam XR used for?

    Often doctors find that medicines are useful for more than one purpose. It is legal to prescribe medicines for "off-label uses" even though the FDA has not formally approved such use. In the case of Keppra, some doctors have found that it is effective against seizure types.

    Who should not take Levetiracetam XR?

    The only people who definitely should not take Keppra XR are those who are allergic to it or any of its inactive ingredients.

    People with kidney disorders need to be extra careful, however. Keppra XR may build up to a level that's too high unless they take very low doses.

    Can Levetiracetam XR be taken with other medicines?

    Sometimes one kind of medicine changes the way another kind of medicine works in the body. Taking Keppra XR does not seem to cause this kind of problem. it does not affect the level of other medicines in the body, and other medicines do not affect the level of Keppra XR.

    What are the effects of Levetiracetam XR on Children?

    Safety and effectiveness of Keppra XR in persons below the age of 16 have not been established.

    In children, regular Keppra has been used primarily to treat partial seizures, ones that begin in a limited area of the brain.

    With regard to regular Keppra, doctors figure out how much medicine to give to young children based mostly on their weight. To keep side effects at a minimum, the doctor probably will prescribe a low dose to start with and increase it slowly. Children usually start with a dose of 10 milligrams (mg) for each kilogram (kg, about 2.2 pounds) of their body weight per day. This would be 250 mg per day for a 55-pound child, for instance. Half this amount is usually given two times a day. After a gradual increase, most children do best taking about 20 to 40 mg per kg per day, Adjusted for weight, this is a little higher than the adult dose because children's bodies eliminate regular Keppra more quickly.

    If a woman takes Levetiracetam XR during pregnancy will it hurt the baby?

    In the United States, the Food and Drug Administration (FDA) assigns each medication to a Pregnancy Category according to whether it has been proven to be harmful in pregnancy. Keppra XR is listed in Pregnancy Category C. This indicates that caution is advised, but the benefits of the medicine may outweigh the potential risks. Studies in animals have shown some harm to the baby, but there haven't been any good studies of results in women.

    Talk to your doctor or another health professional if you are pregnant or plan to become pregnant. We don't yet have enough information to be able to estimate the risk of various types of birth defects that might occur if Keppra XR is taken during pregnancy. We also don't know enough to compare the risk with Keppra XR to the risk with other seizure medicines.

    All women who are capable of becoming pregnant should take at least 0.4 mg (400 mcg) of the vitamin called folic acid every day because it helps to prevent one type of birth defect. (The most well-known of these is spina bifida, in which the spinal cord is not completely enclosed.) Women at high risk, such as those with a history of this kind of defect in a previous pregnancy, should take 4000 mcg (4 mg) daily, beginning before they become pregnant.

    How much Keppra XR is passed through breast milk is not known for certain, but the way the body uses it suggests that probably a large portion does enter the milk. If you want to breast-feed your baby, check with your doctor about what seizure medicine would be best for you.

    What are the effects of Levetiracetam XR on Seniors

    Keppra XR is commonly prescribed for people over 65, but it's important for the doctor to be careful about how much Keppra XR these people take. When people are older than 65 or 70, their kidneys usually don't work as well as before. The kidneys are responsible for removing Keppra XR from the body, so it stays in the body longer.

    Seniors need to increase the dose more slowly than a younger person would.

    Seniors also may be more sensitive to the side effects of Keppra XR. Some of the common side effects, like sleepiness, dizziness, or loss of strength, may worsen problems they had before taking Keppra XR. Seniors also are at greater risk of injury from falls or other accidents resulting from these problems.

    The lack of interactions between Keppra XR and other medicines is an advantage over most other seizure medicines commonly used by seniors.

    What are the dose ranges for Levetiracetam XR?

    The best amount is the amount that completely controls seizures without causing troublesome side effects. It depends on many factors, which are different for every individual. Follow the doctor's directions. Call if you have any questions.

    No one should stop taking Keppra XR or change the amount they take without talking to the doctor first. Stopping any seizure medicine all at once can cause a problem that may be life-threatening.

    Don’t use more than the doctor prescribes. If a little extra (such as an extra tablet or two) is taken by accident, call the doctor for advice. For a larger overdose, call a poison control center or emergency room right away unless you have other specific directions from your doctor.

    To avoid unwanted side effects, the doctor will prescribe a low dose to start and increase it gradually. Young adults usually start by taking 1000 milligrams (mg) once a day. The doctor gradually prescribes more until their seizures are controlled, if side effects are not troublesome. Some people need to take as much as 3,000 mg per day, in two doses.

    People who are over 65 and those with kidney disorders need to take less Keppra XR.

    Read the package insert of Levetiracetam XR

    In the United States, companies that manufacture medicines are required to publish certain kinds of information about each product. This document is commonly known as a “package insert” because it is usually included with each package of the medicine.

    You can also read these documents (also called "prescribing information") online. The U.S. package insert for Keppra XR (levetiracetam) is found at:

    Some of the information may differ in other countries.

    To learn how to read and understand a package insert, see How to read a package insert.


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