Very few people have serious side effects from lacosamide. It is important to be aware of possible reactions and what to do if they happen.
- Read the package insert for more information.
- Call your provider's office right away if any of these problems occur.
Heart rhythm problems: Electrocardiograms (ECGs) of heart rhythms showed a slowing of electrical signal in the heart (called PR prolongation) in some people. The risk of a heart rhythm problem called atrial fibrillation may be higher. These heart rhythm problems are usually rare.
- People with heart problems or on higher doses of lacosamide may be at higher risk.
Low white blood cells: Rarely, a drop in white blood cells may be seen.
Allergic reactions: Allergic reactions happen rarely, but can cause symptoms such as low blood pressure, hives, rash, breathing difficulties, and swelling. It can happen after the first dose or any time when taking lacosamide. Since this can be life-threatening, if these symptoms occur, get immediate medical help.
Suicidal thoughts and behavior: In 2008, the Food and Drug Administration (FDA) reviewed data from drug studies that showed a possible relationship between many seizure medicines and suicidal thoughts and behavior. Together, these thoughts and behavior are called suicidality. According to the FDA’s Alert, among the patients with epilepsy in these drug studies, more had symptoms of suicidality than people taking a placebo or inactive substance - 3.5 of 1,000 people taking a seizure medicine had suicidality compared to 1 of 1,000 people taking a placebo.
- Taking seizure medicines may increase the risk of having suicidal thoughts or actions.
- Do not make any changes to the medicines without first talking to the prescribing health care provider.
- Pay close attention to any day-to-day changes in mood, behavior and actions. These changes can happen very quickly so it is important to be mindful of any sudden differences.
- Be aware of common warning signs that might be a signal for risk of suicide. Some of these are:
- Talking or thinking about wanting to hurt yourself or end your life
- Withdrawing from friends and family
- Becoming depressed or having your depression get worse
- Becoming preoccupied with death and dying
- Giving away prized possessions
- Contact your health care provider before stopping any seizure meicine. This could possibly lead to worsening of seizure and mood.