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Crowdsourcing Advances Seizure Detection and Prediction

504 Global Teams Compete in Model of Collaborative Research
Friday, December 5, 2014

SEATTLE, December 5, 2014 – An international competition using the wisdom of crowds has developed computer algorithms to detect, predict, and ultimately prevent epileptic seizures. A total of 504 teams competed in two challenges: one for Seizure Detection and a second for Seizure Prediction. The contests were hosted by Kaggle, an online platform featuring open competitions for predictive modeling, with participants from all over the world and diverse backgrounds in data analytics, including industry, academia, and hobbyists.

The two challenges were sponsored by the Epilepsy Foundation, the American Epilepsy Society (AES), and the National Institutes of Health’s National Institute of Neurological Disorders and Stroke (NINDS). They set forth goals of accurately detecting and predicting seizure activity in electrical recordings from the brains of individuals with epilepsy and from dogs with spontaneously occurring seizures. Winners were announced on December 6th at the AES 68th Annual Meeting in Seattle during the Presidential Symposium. The competitions were developed and organized by Dr. Ben Brinkmann of the Epilepsy and Neurophysiology Laboratory at the Mayo Clinic (Rochester, Minnesota), along with data scientists at Kaggle. They used shared datasets from the International Epilepsy Electrophysiology Portal, an NINDS-funded platform for collaborative research, data and algorithm sharing in the neurosciences run by Drs. Zack Ives and Joost Wagenaar at the University of Pennsylvania.

“We are very excited to support this competition, along with our partners AES and NINDS, because encouraging innovation and supporting new therapies are core tenants of the Foundation’s mission,” said Philip M. Gattone, president and CEO of the Epilepsy Foundation. “The challenges people with epilepsy face in seizure diagnosis and treatment are truly universal. We were gratified to see hundreds of teams from across the globe embrace the idea of advancing seizure detection and prediction. The contest winners showcase the very best in the ideals of bringing hope and help to people living with seizures in a timeframe that matters.”

"This is an incredibly dynamic and powerful way to do community research and bring new minds into the challenge of epilepsy," said Brian Litt MD, co-chair of competition, professor of neurology and bioengineering at the University of Pennsylvania and director of Penn's Center for Neuroengineering and Therapeutics. "Before this, after 15 years of research, it was only last year that investigators were able to publish seizure prediction better than random. As a result of the contests, in just a few months, teams with no expertise in epilepsy were consistently getting performance as high as 84 percent. In addition, anyone with a computer is able to see what the teams did and can try to improve on their results.”

The first contest – the Seizure Detection Challenge – was won by Michael Hills, an Australian software engineer. In this phase, contestants were charged with analyzing retrospective prolonged intracranial EEG data recorded from four dogs with naturally occurring epilepsy and from eight individuals with medication-resistant seizures during evaluation for epilepsy surgery.

The second contest – the Seizure Prediction Challenge – was a tight seven-way race with top finishers scoring just 0.05 percentage points from each another. The first place was awarded to a team of five engineers and scientists who mutually decided to merge efforts midway through the contest. Drew Abbot, an engineer, and Philip Adkins, a mathematician, work at a small company in Sunnyvale, California, called AiLive. Quang Tien PhD, Simone Bosshard PhD, and Min Chen PhD are scientists at the University of Queensland in Australia. They work in the Center for Advanced Imaging led by David Reutens MD, MBBS. In this phase, teams were challenged to predict seizures accurately from a mixed data set shared from intracranial recordings from humans and dogs with epilepsy. This team predicted seizures with an accuracy of 82 percent.The software and strategies are already being shared openly online by the contest participants, and the unique datasets developed for the competition are being made freely available to researchers worldwide by NINDS, University of Pennsylvania and Mayo Clinic to advance epilepsy research and treatment.

“Advances in neuroengineering have led to first generation implantable devices to treat epilepsy. However, improved therapeutic efficacy is needed. Computational advances providing more accurate seizure detection and prediction are poised to improve therapy,” says Gregory Worrell MD, PhD, co-chair of the AES Presidential Symposium, professor of neurology, biomedical engineering and physiology at the Mayo Clinic. "The model of sharing data and algorithms is critical for generating reproducible research and will rapidly accelerate science. Crowd sourced competitions are an important step in making these devices better."

“Nearly one person in 26 suffers from epilepsy worldwide, and approximately one-third of these individuals have ongoing seizures that are not sufficiently treated with medications or other therapies. New medical devices for preventing seizures are being developed that can utilize the algorithms and strategies used in the seizure detection and prediction challenges,” says Edmund Talley PhD, NINDS program director. “The competitions take a new approach that leverages the expertise of communities outside neurology. It is an approach that could be used to understand and treat disorders beyond epilepsy.”

About Epilepsy

When a person has two or more unprovoked seizures, they have epilepsy, which affects nearly 3 million people in the United States and 65 million people worldwide. This year, another 150,000 people in our country will be diagnosed with epilepsy. Despite all available treatments, four out of 10 people with epilepsy continue to experience uncontrolled seizures while many more experience less than optimal seizure control.

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About the Epilepsy Foundation

The Epilepsy Foundation, a national non-profit with 48 affiliated organizations throughout the United States, has led the fight against seizures since 1968. The Foundation is an unwavering ally for individuals and families impacted by epilepsy and seizures. The mission of the Epilepsy Foundation is to stop seizures and sudden unexpected death in epilepsy (SUDEP), find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies. The Foundation works to ensure that people with seizures have the opportunity to live their lives to their fullest potential. For additional information, please visit www.epilepsy.com.

“Like” the Epilepsy Foundation on Facebook at www.facebook.com/epilepsyfoundationofamerica and follow us on Twitter at www.twitter.com/epilepsyfdn.

 

Our Mission

The mission of the Epilepsy Foundation is to lead the fight to overcome the challenges of living with epilepsy and to accelerate therapies to stop seizures, find cures, and save lives.

 
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