carbamazepine (Tegretol, Tegretol-XR, Carbatrol)
Drugs that increase carbamazepine levels | Drugs that decrease carbamazepine levels |
---|---|
chloramphenicol | none |
erythromycin | |
fluoxetine | |
isoniazid | |
propoxyphene | |
verapamil |
gabapentin (Neurontin)
Drugs that increase gabapentin levels | Drugs that decrease gabapentin levels |
---|---|
none | antacids (Maalox TC) |
lamotrigine (Lamictal)
Drugs that increase lamotrigine levels | Drugs that decrease lamotrigine levels |
---|---|
sertraline (based on a case report only) | oral contraceptives |
levetiracetam (Keppra)
Drugs that increase levetiracetam levels | Drugs that decrease levetiracetam levels |
---|---|
none | none |
phenobarbital
Drugs that increase phenobarbital levels | Drugs that decrease phenobarbital levels |
---|---|
isoniazid | none |
phenytoin (Dilantin, Phenytek)
Drugs that increase phenytoin levels | Drugs that decrease phenytoin levels |
---|---|
5-FU | antacids |
allopurinol | ASA (total phenytoin concentrations may decrease due to protein-binding displacement, but unbound concentrations should remain unaltered) |
amiodarone | |
chloramphenicol | |
cimetidine | |
diltiazem | carmustine |
disulfiram | ethanol (chronic ingestion) |
fluconazole | folate (high dose) |
fluoxetine | methotrexate |
ibuprofen | rifampin |
imipramine | sucralfate |
INH | vinblastine |
methylphenidate | |
metronidazole | |
omeprazole | |
propoxyphene | |
ritonavir | |
ticlopidine | |
trimethoprim/sulfa |
topiramate (Topamax)
Drugs that increase topiramate levels | Drugs that decrease topiramate levels |
---|---|
none | none |
valproate (Depakote, Depakote ER, Depakene, valproic acid)
Drugs that increase valproate levels | Drugs that decrease valproate levels |
---|---|
acetylsalicylic acid (ASA) | none |
isoniazid |
Adapted from: Schachter SC. Treatment of seizures. In: Schachter SC, Schomer DL, eds. The comprehensive evaluation and treatment of epilepsy. San Diego, CA: Academic Press; 1997. p. 61-74. With permission from Elsevier (www.elsevier.com).
Reviewed By:
Barry Gidal PharmD
on:
Sunday, February 1, 2004