carbamazepine (Tegretol, Tegretol-XR, Carbatrol)

Drugs that increase carbamazepine levels Drugs that decrease carbamazepine levels
chloramphenicol none
erythromycin
fluoxetine
isoniazid
propoxyphene
verapamil

 

gabapentin (Neurontin)

Drugs that increase gabapentin levels Drugs that decrease gabapentin levels
none antacids (Maalox TC)

 

lamotrigine (Lamictal)

Drugs that increase lamotrigine levels Drugs that decrease lamotrigine levels
sertraline (based on a case report only) oral contraceptives

 

levetiracetam (Keppra)

Drugs that increase levetiracetam levels Drugs that decrease levetiracetam levels
none none

 

phenobarbital

Drugs that increase phenobarbital levels Drugs that decrease phenobarbital levels
isoniazid none

 

phenytoin (Dilantin, Phenytek)

Drugs that increase phenytoin levels Drugs that decrease phenytoin levels
5-FU antacids
allopurinol ASA (total phenytoin concentrations
may decrease due to protein-binding
displacement, but unbound concentrations
should remain unaltered)
amiodarone
chloramphenicol
cimetidine
diltiazem carmustine
disulfiram ethanol (chronic ingestion)
fluconazole folate (high dose)
fluoxetine methotrexate
ibuprofen rifampin
imipramine sucralfate
INH vinblastine
methylphenidate  
metronidazole  
omeprazole  
propoxyphene  
ritonavir  
ticlopidine  
trimethoprim/sulfa  

 

topiramate (Topamax)

Drugs that increase topiramate levels Drugs that decrease topiramate levels
none none

 

valproate (Depakote, Depakote ER, Depakene, valproic acid)

Drugs that increase valproate levels Drugs that decrease valproate levels
acetylsalicylic acid (ASA) none
isoniazid

 

Adapted from: Schachter SC. Treatment of seizures. In: Schachter SC, Schomer DL, eds. The comprehensive evaluation and treatment of epilepsy. San Diego, CA: Academic Press; 1997. p. 61-74. With permission from Elsevier (www.elsevier.com).

Authored By: 
Steven C. Schachter MD
I<
Reviewed By: 
Barry Gidal PharmD
on: 
Sunday, February 1, 2004