Cytochrome P-450 Isoenzyme Antimicrobial Anticonvulsant
Substrate Inducer Inhibitor Substrate Inducer Inhibitor
1A2 Ritonavir Rifampin Ciprofloxacin Diazepam Carbamazepine  
Ritonavir Clarithromycin Phenobarbital
Erythromycin Phenytoin
Isoniazid Primidone
Ketoconazole
Levofloxacin
Ritonavir
2A6 Ritonavir   Ritonavir   Phenobarbital  
2B6         Phenobarbital  
Phenytoin
Primidone
2C   Rifampin Isoniazid   Carbamazepine  
Ketoconazole Phenobarbital
Phenytoin
Primidone
2C8   Rifampin   Carbamazepine Carbamazepine  
Diazepam Phenobarbital
Phenytoin
Primidone
2C9 Dapsone Fluconazole Chloramphenicol Phenytoin Carbamazepine Valproic acid
Metronidazole Rifampin Isoniazid Phenobarbital
Ritonavir Ketoconazole Phenytoin
Metronidazole
Ritonavir
Sulamethox
axole
trimethoprim
Sulfonamides
2C18   Rifampin     Carbamazepine  
Phenobarbital
Phenytoin
2C19 Pentamidine Rifampin Fluconazole Phenobarbital Carbamazepine Felbamate
Ritonavir Isoniazid Phenytoin Phenobarbital Oxcarbazepine
Ketoconazole Topiramate Phenytoin Topiramate
Ritonavir Valproate
2D6   Chloroquine   Tagabine Valproate  
Quinidine
Ritonavir
2E1 Dapsone Isoniazid Ritonavir      
Isoniazid
Ritonavir
3A3/4 Clarithromycin Griseofulvin   Carbamazepine Carbamazepine  
Clindamycin Nafcillin Clonazepam Oxcarbazepine
Dapsone Rifabutin Diazepam Phenobarbital
Erythromycin Tiagabine Phenytoin
Indinavir Primidone
Itraconazole
Ketoconazole
Miconazole
Nelfinavir
Quinidine
Rifamipin
Ritonavir
Saquinavir
3A5-7 Quinidine Rifampin Clotrimazole   Phenobarbital  
Ketoconazole Phenytoin
Metronidazole Primidone

Data adapted from CF Lacy, LL Armstrong, MP Goldman. Drug Information Handbook. Hudson, OH: Lexi-Comp, 2000; 1092-1100; P Hantson, F Leonard, JM Maloteaux, P Maheiu. How epileptogenic are the recent antibiotics? Acta Clin Belg 1999; 54:80-87

Authored By: 
CF Lacy
LL Armstrong
MP Goldman