Tegretol, Carbatrol

Renal impairment

The absorption and clearance of carbamazepine do not appear to be influenced by renal impairment.42 Carbamazepine has a significant antidiuretic effect, however, and may promote fluid retention.


Carbamazepine is poorly soluble in water and is 80% protein bound. As expected, hemodialysis has little effect on carbamazepine plasma concentration.43

Adapted from: Browne TR. Renal disorders. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;49-62. 
With permission from Elsevier (www.elsevier.com).

Reviewed By: 
Steven C. Schachter, MD
Saturday, January 31, 2004