Tegretol, Carbatrol
Renal impairment
The absorption and clearance of carbamazepine do not appear to be influenced by renal impairment.42 Carbamazepine has a significant antidiuretic effect, however, and may promote fluid retention.
Hemodialysis
Carbamazepine is poorly soluble in water and is 80% protein bound. As expected, hemodialysis has little effect on carbamazepine plasma concentration.43
Adapted from: Browne TR. Renal disorders. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;49-62.
With permission from Elsevier (www.elsevier.com).
Reviewed By:
Steven C. Schachter, MD
on:
Saturday, January 31, 2004
