120. Benowitz NL, Simon RP, Copeland JR. Status epilepticus: divergence of sympathetic activity and cardiovascular response. Ann Neurol 1986;19:197.

121. Bayne LL, Simon RP. Systemic and pulmonary vascular pressures during generalized seizures in sheep. Ann Neurol 1981;10:566.

122. Simon RP, Bayne LL, Tranbaugh RF, Lewis FR. Elevated pulmonary lymph flow and protein content during status epilepticus in sheep. J Appl Physiol 1982;52:91.

123. Darnell JC, Jay SJ. Recurrent postictal pulmonary edema: a case report and review of the literature. Epilepsia 1982;23:71.

124. Terrence CF, Rao GR, Perper JA. Neurogenic pulmonary edema in unexpected, unexplained death of epileptic patients. Ann Neurol 1981;9:458.

125. Walczak TS, Leppik IE, D'Amelio M, et al. Incidence and risk factors in sudden unexpected death in epilepsy: a prospective cohort study. Neurology. 2001;56:519-525.

126. Johnston SC, Horn JK, Valnete J, Simon RP. The role of hypoventilation in a sheep model of epileptic sudden death. Ann Neurol 1995;37:531–537.

127. Johnston SC, Siedenberg R, Min J, et al. Central apnea and acute cardiac ischemia in a sheep model of epileptic sudden death. Ann Neurol 1997;42:588–594.

128. Nashef L, Walker F, Allen P, et al. Apnea and bradycardia during epileptic seizures: relation to sudden death in epilepsy. J Neurol Neurosurg Psychiatry 1996;60:297–300.

129. Walker F, Fish DR. Recording respiratory parameters in patients with epilepsy. Epilepsia 1997;38[Suppl 11]:41–42.

130. So EL, Sam MC, Lagerlund TL. Postictal central apnea as a cause of SUDEP: evidence from a case of nearSUDEP. Epilepsia 1999;40[Suppl 7]:90–91.

131. Bird JM, Dembny KA, Sandeman D, Butler S. Sudden unexplained death in epilepsy: an intracranially monitored case. Epilepsia 1997;38[Suppl 11]:52–56.

132. Nashef L, Garner S, Fish D. Circumstances of death in sudden death in epilepsy: interviews of bereaved relatives. J Neurol Neurosurg Psychiatry 1998;64:349–352.

133. Kaada BR. Somatomotor, autonomic, and electrocortico- graphic responses to electrical stimulation of “rhinencephalic” and other structures in primates, cat, and dog. Acta Physiol Scand 1951;24:1.

134. Kaada BR, Jasper H. Respiratory responses to stimulation of temporal pole, insula and hippocampal and limbic gyri in man. Arch Neurol Psychiatry 1952;68:609.

135. Nelson DA, Ray CD. Respiratory arrest from seizure discharges in limbic system. Arch Neurol 1968;19:199.

136. Maskill D, Murphy K, Mier A, et al. Motor cortical representation of the diaphragm in man. J Physiol (Lond) 1991;443:105.

137. Anticonvulsant Prescribing Guide. PDR Pocket Guide to Prescription Drugs. Montvale, NJ: Medical Economics Company, 2000;6,14–15.

138. Jozefowicz RF. Neurologic manifestations of pulmonary disease. Neurol Clin 1989;7:605–616.

139. Killburn KH. Neurologic manifestations of respiratory failure. Arch Intern Med 1965;116:409.

140. Brierley JB, Graham DI. Hypoxia and vascular disorders of the central nervous system. In JH Adams, JA Corsellis, LW Duchen (eds), Greenfield’s Neuropathology (4th ed). New York: Wiley, 1984.

141. Sieker HO, Hickam JB. Carbon dioxide intoxication. Medicine (Baltimore) 1956;35:389.

142. Woodbury DM, Karler R. The role of carbon dioxide in the nervous system. Anesthesiology 1960;21:687.

143. Simpson T. Papilledema in emphysema. BMJ 1948; 2:639.

144. Miller A, Bader RA, Bader ME. The neurologic syndrome due to marked hypercapnia, with papilledema. Am J Med 1962;33:309.

145. Ehrenberg B. Importance of sleep restoration in co- morbid disease: effect of anticonvulsants. Neurology 2000;54[Suppl 1]:S33–S37.

146. Wyler AR, Weymuller EA. Epilepsy complicated by sleep apnea. Ann Neurol 1981;9:403–404.

147. Devinsky O, Ehrenberg B, Barthlen GM, et al. Epilepsy and sleep apnea syndrome. Neurology 1994;44:2060–2064.

148. Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. Annu Rev Med 1976;27:465.

149. Tobin MJ, Cohn MA, Sacner MA. Breathing abnormalities during sleep. Arch Intern Med 1983;143:1221.

150. Koh S, Ward SL, Lin M, Chen LS. Sleep apnea treatment improves seizure control in children with neurodevelopmental disorders. Pediatr Neurol 2000;22:36–39.

151. Schachter SC. Iatrogenic seizures. Neurol Clinics 1998; 16:157–170.

152. Paloucek FP, Rodvold KA. Evaluation of theophylline overdoses and toxicities. Ann Emerg Med 1988;17:135.

153. Gaudreault P, Guay J. Theophylline poisoning: pharmacological considerations and clinical management. Med Toxicol 1986;1:169.

154. Edvinsson L, Fredholm BB. Characterization of adenosine receptors in isolated cerebral arteries of cat. Br J Pharmacol 1983;80:631.

155. Garcia PA, Alldredge BK. Drug-induced seizures. Neurol Clin 1994;12:85–99.

156. Bahls FH, Ma KK, Bird TD. Theophylline associated seizures with “therapeutic” or low toxic serum concentrations: risk factors for serious outcome in adults. Neurology 1991;41:1309–1312.

157. Zwillich CW, Sutton FD, Neff TA, et al. Theophylline-induced seizures in adults: correlation with serum concentrations. Ann Intern Med 1975;82:784.

Adapted from: Sepkuty JP and Kaplan PW. Hematologic and pulmonary disorders. In: Ettinger AB and Devinsky O, eds. Managing epilepsy and co-existing disorders. Boston: Butterworth-Heinemann; 2002;209–228.
With permission from Elsevier (www.elsevier.com).