AGE OF ONSET OF EPILEPSY

Inherited metabolic diseases

Neonatal period to early infancy

  • Pyridoxine dependency, biotinidase deficiency
  • Amino acidopathies, organic acidopathies
  • Urea cycle disorders
  • Menkes' syndrome, Alpers' disease
  • Glucose transporter protein deficiency
  • Molybdenum cofactor deficiency
  • Peroxisomal and mitochondrial diseases

Late infancy to early childhood

  • Lysosomal storage diseases
  • Neuronal ceroid-lipofuscinoses, Haltia-Santavuori variant (CLN1)
  • Leigh disease
  • Cockayne's syndrome

Childhood and adolescence

  • Juvenile Gaucher's disease
  • Juvenile GM2 gangliosidosis
  • Multiple sulfatase deficiency
  • Sanfilippo's syndrome
  • Sialidosis
  • Neuronal ceroid-lipofuscinosis, juvenile (CLN3)
  • MELAS, MERRF
  • Unverricht-Lundborg disease
  • Lafora's disease

MELAS = mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
MERRF = myoclonic epilepsy with ragged red fibers.

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