Some men taking antiepileptic drugs experience decreased libido and potency, low sperm count, decreased sperm viability, and decreased likelihood of ovum fertilization. Herzog et al4 assessed 20 unselected men with complex partial seizures for comparison with impotent men seen in an endocrine clinic. Hypogonadotropism was found in 20% of men with epilepsy compared to 25% of impotent men, hypergonadotropism in 10% and 7%, respectively, and hyperprolactinemia in 10% and 8%, respectively. They suggested involvement of the temporal lobe discharges because of the similar incidence of endocrine disorders in this small group of men with epilepsy matching the men diagnosed with impotence.

Authored By: 
Joyce Cramer
Reviewed By: 
Steven C. Schachter MD
Orrin Devinsky MD
Wednesday, September 1, 2004