Category Drug Comment
Antiasthmatics aminophylline
theophylline
Especially but not exclusively above therapeutic levels
Antibiotics isoniazid
lindane
metronidazole
nalidixic acid
penicillins
Vitamin B6 supplement may protect
Especially with renal failure
Antidepressants tricyclics
serotonin-specific agents
bupropion
Rarely a practical problem;
desipramine may be preferable
General anesthetics enfluraneketamine  
Hormones insulin By means of hypoglycemia
prednisone By means of hypocalcemia
estrogen Especially without progesterone
Immunosuppressants chlorambucil
cyclosporine a
 
Local anesthetics lidocaine
bupivicaine
procaine
 
Narcotics fentanyl
meperidine
pentazocine
propoxyphene
 
Psychostimulants amphetamines
cocaine
methylphenidate
phenylpropanolamine
 
Neuroleptics clozapine
phenothiazines
butyrophenones
1%-4% of all patients, depending on dose
Molindone, thioridazine, fluphenazine least likely
Other anticholinergics
anticholinesterases
antihistamines
baclofen
heavy metals
hyperbaric oxygen
lithium
mefenamic acid
oral hypoglycemics
oxytocin
By means of water intoxication

Adapted from: Bromfield EB. Epilepsy and the elderly. In: Schachter SC, Schomer DL, eds. The comprehensive evaluation and treatment of epilepsy. San Diego, CA: Academic Press; 1997. p. 233-254. With permission from Elsevier (www.elsevier.com).

Authored By: 
EB Bromfield
I<
Reviewed By: 
Steven C. Schachter MD
on: 
Monday, May 31, 2004