Antipsychotic Incidence of Seizures (%) Sources
Chlorpromazine
  <900 mg/day 0.3-5.0 94,98,99
  >1 g/day 10 94
Clozapine
  All doses 1-10 90,91,93-97
  <300 mg/day 1-2 89,92,95
  300-600 mg/day 0.8-4.0 89,92,95
  >600 mg/day 2.1-14.0 89,92,95
Fluphenazine <1.0-1.2 92,94,97
Haloperidol No reports of incidence  
Mesoridazine <1.0-1.2 92,94,97
Loxapine 19 99
Molindone No reports of incidence  
Olanzapinea 0.88 92
Perphenazine <1.0-1.2 92,94,97
Pimozide No reports of incidence  
Prochlorperazine <1.0-1.2 92,94,97
Quetiapineb <1 92,94,97
Risperidonec 0.3 88
Thioridazine <1.0-1.2 92,94,97
Thiothixene No reports of incidence  
Trifluoperazine <1.0-1.2 92,94,97
Triflupromazine <1.0-1.2 92,94,97

aProduct information. Olanzapine (Zyprexa). Eli Lilly Company, Indianapolis, IN, 1997.
bProduct information. Quetiapine (Seroquel). Zeneca Pharmaceuticals, Wilmington, DE, 1997.
cProduct information. Risperidone (Risperdal). Jansen Pharmaceutica, Inc., Titusville, NJ, 1997.

From: Barry JJ and Huynh N. Psychotropic drug use in patients with epilepsy and developmental disabilities. In: Devinsky O and Westbrook LE, eds. Epilepsy and Developmental Disabilities. Boston: Butterworth-Heinemann; 2001;205-217.
With permission from Elsevier (www.elsevier.com).

Authored By: 
JJ Barry and N Huynh
Reviewed By: 
Steven C. Schachter MD
on: 
Sunday, February 29, 2004