Antidepressants Seizure Incidence (%)
TCAs and tetracyclic antidepressants
Amitriptyline <0.1-0.3
Amoxapine 24.5-36.4
Clomipramine 0.7-3.0
Desipramine <0.1
Doxepin <0.1
Imipramine <0.1-0.9
Maprotiline 0.4-15.6
Nortriptyline <0.1
Protriptyline <0.1
SSRI and SNRI
Citalopram <0.1
Fluoxetine <0.1-0.2
Fluvoxamine <0.2
Paroxetine <0.1
Sertraline <0.1
Venlafaxine <0.26
Other antidepressants
Bupropion 0.6-1.0
>450 mg/day 0.6-2.19
SR 400 mg/day 0.4
SR 300 mg/day 0.1
Mirtazapine <0.1
Nefazodone NA
Trazodone <0.1

TCAs = tricyclic antidepressants
SNRI = serotonin-norepinephrine reuptake inhibitor
SSRI = selective serotonin reuptake inhibitor
SR = sustained-release formula
NA = limited information

Adapted from: Barry JJ and Huynh N. Psychotropic drug use in patients with epilepsy and developmental disabilities. In: Devinsky O and Westbrook LE, eds. Epilepsy and Developmental Disabilities. Boston: Butterworth-Heinemann; 2001;205-217.
With permission from Elsevier (www.elsevier.com).

Authored By: 
Steven C. Schachter MD
Authored Date: 
05/2004