Carbamazepine (Tegretol, Tegretol-XR, Carbatrol)
| AEDs that increase levels |
AEDs that decrease levels |
| felbamate (increases carbamazepine epoxide) |
felbamate |
| valproate (increases carbamazepine epoxide) |
phenobarbital |
| phenytoin |
primidone |
Felbamate (Felbatol)
Felbamate is recommended for use only by patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia, liver failure, or both is deemed acceptable in light of the benefits of its use.
| AEDs that increase levels |
AEDs that decrease levels |
| valproate |
carbamazepine |
| phenytoin |
phenobarbital |
Gabapentin (Neurontin)
| AEDs that increase levels |
AEDs that decrease levels |
| none |
none |
Lamotrigine (Lamictal)
| AEDs that increase levels |
AEDs that decrease levels |
| valproate |
carbamazepine |
| phenytoin |
phenobarbital |
Levetiracetam (Keppra)
| AEDs that increase levels |
AEDs that decrease levels |
| none |
none |
Phenobarbital
| AEDs that increase levels |
AEDs that decrease levels |
| valproate |
phenytoin (variable interaction) |
| phenytoin (variable interaction) |
|
Phenytoin (Dilantin, Phenytek)
| AEDs that increase levels |
AEDs that decrease levels |
| ethosuximide (variably reported) |
carbazepine |
| felbamate |
|
| oxcarbamazepine |
|
| valproate (unbound levels) |
|
| topiramate |
|
Tiagabine (Gabitril)
| AEDs that increase levels |
AEDs that decrease levels |
| none |
carbamazepine |
| |
phenytoin |
| |
phenobarbital |
Valproate (Depakote, Depakote ER, Depakene, valproic acid)
| AEDs that increase levels |
AEDs that decrease levels |
|
| felbamate |
carbamazepine |
| |
phenobarbital |
| |
phenytoin |
Adapted from: Schachter SC. Treatment of seizures. In: Schachter SC, Schomer DL, eds. The comprehensive evaluation and treatment of epilepsy. San Diego, CA: Academic Press; 1997. p. 61-74.
With permission from Elsevier (www.elsevier.com).
