(Zonisimide) Really need some advice.

That's a let down that you have the seizures and anxiety after being seizure free for 4 months.  Your neurologist will probably direct you to a psychiatrist who will tinker with adding other pills for depression (which can sometimes upset the seizure balance more or just leave you more tired).  I hope that there are other anti seizure meds you have not tried yet that your doctor can switch you to. I started zonisamide (added to my Dilantin regimen) in March with two 100 mg capsules at bedtime.  After five or six weeks I noticed some mild depression and I soon really noticed problems with anger and aggression.  Some mild focal seizures still occurred.  When I first complained to my epilepsy specialist he blamed my anxiety on upcoming surgery.  He also encouraged me to wait until after surgery.  Serious aggressive events occurred and I insisted I be cut back.  Doctor has me on 100 mg now and am feeling better.  I am looking forward to RNS surgery and will later ask to get off.  If seizures would be controlled then it might be worth it to try adding other meds to control the side effects.  But if the seizures happen along with the bothersome side effects it's time to tell doc you want to try something else.  If your one of those who has tried many anti seizure drugs and still have problems you need to be talking with a specialist about alternative treatments.  An epilepsy specialist is encouraged even if the pills work.

Hi eoviaho, Thank you for sharing your experience. It’s important that you follow-up with your neurologist to discuss any changes in side effects, behaviors, symptoms, or seizure types, https://www.epilepsy.com/learn/types-seizures, and to determine what treatment is best for you. https://www.epilepsy.com/learn/challenges-epilepsy/moods-and-behavior/medications-and-mood Additionally,you may want to consider with your doctor having a device that can help track seizures,by visiting https://www.dannydid.org/ , and by keeping a seizure diary https://www.epilepsy.com/living-epilepsy/epilepsy-foundation-my-seizure-diary as another self-management tool. These tools may be helpful in identifying & tracking seizures, other symptoms, managing medication & other therapies, recognizing triggers and health events that may affect seizures and wellness, which you can share with your providers. https://www.epilepsy.com/learn/managing-your-epilepsyIt is common for those living with epilepsy to experience feelings of depression and anxiety depression, https://www.epilepsy.com/living-epilepsy/healthy-living/emotional-health/overview-depression  & https://www.epilepsy.com/learn/challenges-epilepsyIt is important to recognize that epilepsy is more than just seizures, overall well-being and emotional health is just as important, https://www.epilepsy.com/living-epilepsy/healthy-living/emotional-healthIt can be helpful to connect with other people who live with epilepsy,  to ask questions, share experiences, find & give support to each other, by contacting your local Epilepsy Foundation at epilepsy.com/localsupport  &  www.epilepsy.com/affiliates , to find support groups, events, and programs in your community. Additionally, our Epilepsy and Seizures 24/7 Helpline: 1-800-332-1000, contactus@efa.org,  epilepsy.com/helpline  , where a trained information specialist can assist in  connecting you to resources, provide referrals & additional support.