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SK Life Sciences, YKP 3089

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Tx name YKP3089
Description efficacy for epilepsy, pain, bipolar, anxiety
Company SK Life Sciences
Status  
Overview Novel mechanism of action, no details revealed
PK Dose proportionality, Well tolerated, No Food effect, No Oral Contraceptive interaction, Good Mass Recovery, Proof of Concept correlation with Plasma levels,  Once a day dosing
indications Broad spectrum Epilepsy, plus potential  therapeutic for  Neuropathic Pain, Bipolar Disorder, Anxiety
preclin data Anticonvulsant Profile: Broad spectrum activity in Rat & Mice (i.p., p.o.)
Pain Profile: Potent efficacy in Chung & Bennett models in Rat
Bipolar Profile: Potent efficacy in Hippocampal Kindling, Bipolar Mania  models
Anxiolytic Profile: Active in diverse AX models in Rat & Mice (i.p., p.o.)
preclin tox  
Phase 1 Single & multi dose studies completed, food effect, oral contraceptive DDI, mass balance, proof of concept photo-sensitivity study
Phase 2  
Phase 3  
Adverse effects Low QTc prolongation potential
publications  
IP Patent issues 2009
Potential problems Clinical trial recruitment, minimizing placebo effect.
Timeline  
Financial Status  
Partnerships Seeking partner before pursuing multiple indications
ETP Support  

President
President
Created by President 07/23/2010 at 02:43pm
admin
admin
Edited by admin 09/2/2010 at 01:12pm

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