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Take control of your epilepsy and seizures. Seizure management has never been easier.
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Philanthropic Funding Provided by: Epilepsy Therapy Project
| Tx name | Galanin |
| Description | Gene therapy |
| Company | Asklepios |
| Status | Pre-clinical |
| Overview | Infusion of galanin into the CNS significantly attenuates seizure activity in a number of animal models. Galanin knockout mice exhibit a significantly greater seizure sensitivity while galanin overexpressing mice exhibit a reduced seizure sensitivity. Galanin exhibits neuroprotective actions. AAV delivery method Efficiently mediates stable long term gene expression in the CNS. Excellent safety profile (Pre-clinical & Clinical. Potential seizure reduction without loss of cognitive function; Neuro-protective & anticonvulsant benefits with single treatment |
| PK | N/A |
| indications | Mesial temporal lobe epilepsy |
| preclin data | |
| preclin tox | Small animal POC - Completed Phase I SBIR Awarded - 9/2008 Top level toxicity - Completed Small animal model dose response - Completed Preliminary Primate Studies - Completed Pre pre-IND Interaction ~ Q1/2010 Phase II SBIR Submission ~ Q2/2010 |
| Phase 1 | Phase I Clinical trial at Yale & Emory, $2.5M required, 2012 Initiation. Demonstrate safety of Galanin gene delivery. This will establish Dosing of Galanin gene delivery, and demonstrate the initial efficacy of Galanin gene delivery. |
| Phase 2 | |
| Phase 3 | |
| Adverse effects | |
| publications | |
| IP | Biological Nano Particle (BNP) is a platform vector technology that has been developed over the last 35 years based on parvovirus research and engineering by Dr. Jude Samulski at the University of North Carolina at Chapel Hill. Over $35 M has been invested in BNP development to date. The technology was exclusively licensed to AskBio in 2003. Mature IP Portfolio - >22 issued patents, >50 active applications. IP licensed by GSK, Merck, Medtronic & others. Unique IP improves upon efficiency and safety and has been validated in the clinic Multiple POC and clinical studies support CNS gene delivery system. Epilepsy program builds on IP for anti-epileptic neuropeptide gene expression. |
| Potential problems | Rodent models - early risk mitigation: Preliminary behavioral and cognitive testing; Optimization of expression cassette; Top level toxicity Primate studies: Proof of principle in cortically robust species; Accurate test of Clinical Approach Comparison of Galanin Delivery and Resection procedures |
| Timeline | |
| Financial Status | |
| Partnerships | |
| ETP Support | Grant Spring 2010 |
| Title | Posted | |
|---|---|---|
| Nocturnal seizures | May 25, 2012 | |
| nocturnal11 | ||
| Lamictal & Seizure questions - help??? | May 25, 2012 | |
| PPlex | ||
| Severe Epilepsy And Pregnancy | May 25, 2012 | |
| AmyBoop88 | ||
| 7 yr old seizures and autism/hearing loss/adhd, etc | May 25, 2012 | |
| jackjack | ||
| epilepsy and hormonal effects | May 25, 2012 | |
| cindyloowho | ||
| Tried Potiga yet? | May 24, 2012 | |
| tcameron | ||
| Can exercise induce seizures? | May 24, 2012 | |
| MichaelK | ||
| Lamictal Nausea, Dizzy Spells | May 24, 2012 | |
| karyliin6 | ||
| Anyone on Lamictal AND Keppra? | May 24, 2012 | |
| Bloodyrose | ||
| Paying for your seizure pills with no insurance? | May 24, 2012 | |
| Tatianalee | ||
| View all Forums | ||
| Title | Page Views | |
|---|---|---|
| my.epilepsy.com Updates | 20,619 | |
| epi_help | ||
| topamax and weight loss | 19,330 | |
| alexia mom | ||
| kepra | 19,244 | |
| brian mattingly | ||
| Possible cure for absence seizures | 16,388 | |
| pdl1 | ||
| How exactly do aura's feel | 14,077 | |
| WendyBendy | ||
| Sexual Side Effects | 13,524 | |
| George R | ||
| MEDICAL ALERT I.D.'s | 12,453 | |
| picnupthepcs | ||
| Over 40 Different Types Of Seizures - Revised | 10,443 | |
| spiz | ||
| electrical shock in head? | 10,083 | |
| Maggie | ||
| Weight Gain and Depakote | 9,011 | |
| galinda | ||
| View all Forums | ||
| Title | Posted | |
|---|---|---|
| Update 2012 -- lots has happened! | May 25, 2012 | |
| ninabva68 | ||
| My Blog Disappeared! Can't my seizures too? | May 24, 2012 | |
| MichaelK | ||
| SEIZURES ARE CHANGING. WHY? WHAT KIND AM I HAVING NOW? BRAIN EXPLOSION I FELT IS A MYSTERY TO ME | May 24, 2012 | |
| ROCKNROLL | ||
| Hyperventilation & epilepsy, a way to help yourself. | May 23, 2012 | |
| buteykomike | ||
| Medicine adjustments | May 23, 2012 | |
| fashionlove45 | ||
| NOT YELLING, VISUALLY IMPAIRED. POSTICTAL SHOPPING. ANYONE ELSE WITH THIS PROBLEM? TBI AND SHOPPING | May 22, 2012 | |
| ROCKNROLL | ||
| Seizures and medical marijuana | May 21, 2012 | |
| seizureprone134 | ||
| being unigue and being hypocrite | May 20, 2012 | |
| futuer poet | ||
| Coming out? | May 19, 2012 | |
| fashionlove45 | ||
| RWAY40 | May 19, 2012 | |
| rway40 | ||
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| Title | Page Views | |
|---|---|---|
| my partial complex seizures | 4,540 | |
| Zanna1211 | ||
| Topomax... The Dreaded......... | 3,787 | |
| Dr Jason | ||
| Brain Zaps, tics & twitches | 3,586 | |
| JudiS | ||
| How can you tell if a sleep seizure happens? | 3,545 | |
| epl_controller | ||
| Feeling Sick | 3,308 | |
| JBJ1984 | ||
| side effects of phenobarb. | 3,215 | |
| pksmom | ||
| Tegretol XR and ANXIETY meds | 2,904 | |
| Butterflygrl | ||
| TYLENOL, AEDs & SEIZURES | 2,836 | |
| cmscribbles | ||
| Nonepileptic "Events" vs. "Seizures" | 2,711 | |
| teft | ||
| newborn seizure | 2,256 | |
| Sunny_80 | ||
| View all Blogs | ||
| Title | Posted | |
|---|---|---|
| Angela-48 | May 11, 2012 | |
| ANGELA-48 | ||
| Babies with seizures | May 5, 2012 | |
| gabrielsmommy121911 | ||
| Parent and Family Support Group Newton Kansas | Mar 13, 2012 | |
| Brown67114 | ||
| No more driving | Mar 9, 2012 | |
| Amy829 | ||
| Audubon, Pennsylvania (King of Prussia area) Parents of Kids with Epilepsy Looking to connect with others in thier area | Mar 7, 2012 | |
| ajssoscia | ||
| People who have epilepsy and are parents of young children, step children or pregnant. | Feb 27, 2012 | |
| kjsdestiny | ||
| Had the worse seizure of my life last night! Complex Partial | Feb 8, 2012 | |
| jlamont | ||
| Self-Management of Medication | Feb 7, 2012 | |
| columbia.epilepsy.study | ||
| Dravet Spectrum Disorder | Feb 4, 2012 | |
| mytboy | ||
| Diving with eplilepsy | Feb 1, 2012 | |
| p59 | ||
| View all Groups | ||
| Title | Posted | |
|---|---|---|
| Imagining the past | May 25, 2012 | |
| jrgeorge | ||
| Feeling Epilepsy as a part of Life....... | May 25, 2012 | |
| Avnish | ||
| My life with epilepsy | May 24, 2012 | |
| BigTom_85 | ||
| I thought there was nothing wrong | May 24, 2012 | |
| Mendoza87 | ||
| New to this | May 23, 2012 | |
| kitkat2503 | ||
| Is it Emotional | May 23, 2012 | |
| frustrated1965 | ||
| Adjusting with the thought of epilepsy after misdiagnosis for over 20 years | May 22, 2012 | |
| goofyheather | ||
| Continuing with life | May 21, 2012 | |
| nastaran | ||
| Working my life around having epilepsy | May 21, 2012 | |
| 1505loupylou | ||
| The frustration of not knowing exaclty what is wrong... | May 20, 2012 | |
| cag122 | ||
| View all Stories | ||
| Title | Page Views | |
|---|---|---|
| Jessica Roiz | 2,433 | |
| kroiz | ||
| my story | 562 | |
| snoby | ||
| Temporal Lobe Epilepsy | 561 | |
| Always Have On Clean Underwear | 508 | |
| crashllama | ||
| my brain has died a thousand deaths........... | 476 | |
| banffgirl | ||
| Kelly's Life With Epilepsy | 472 | |
| kjcanada1979 | ||
| What My Seizures Are Like...... | 421 | |
| javaman | ||
| Nocturnal grand mal seizures (primary generalized epilepsy) | 395 | |
| karalyeva | ||
| Life......... | 376 | |
| dizzygal | ||
| My Daily Philosophy..... | 366 | |
| KatieFerguson88 | ||
| View all Stories | ||