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Take control of your epilepsy and seizures. Seizure management has never been easier.
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| Tx name | 2DG ( 2-deoxy-D-glucose ) |
| Description | Glucose analog exploiting metabolic regulation of neural plasticity |
| Company | NeuroGenomeX |
| Status | |
| Overview | Novel pattern of effectiveness in pre-clinical models, Lacks debilitating side effects of current therapies, Slows long-term progression of the disease, Novel acute and chronic anti-epilepsy mechanism of action in pre-clinical models, 2DG concentrates to the areas of epileptic activity. MOA: Glycolytic inhibition is a novel anticonvulsant mechanism possibly related to the ketogenic diet; 2DG regulates synaptic vesicle release by activity-dependent mechanisms; 2DG prevents seizure-induced gene expression contributing to chronic epilepsy progression by metabolic regulation of NRSF and NADPH-CtBP dependent transcription. 2DG is preferentially delivered to epileptic foci by neurovascular coupling and activity-dependent uptake, enabling “post-seizure” administration. In vivo models show unique efficacy pattern. In vitro models suggest that actions at the cellular level are potentially “broad-spectrum” against different mechanisms of network synchronization. |
| PK | Oral (liquid or capsule); IV; IM; SC; Potentially novel methods of delivery through device therapies. |
| indications | |
| preclin data | In vivo animal models of acute & chronic epilepsy: Two-fold slowing of kindled seizure induction & progression evoked from different brain sites (UW Madison); minimum dose of 37.5 mg/kg* Effective against seizure progression when administered up to 10 minutes after a seizure. Two-fold slowing of latency to status epilepticus onset by kainic acid and pilocarpine (Lian et al 2008); Protection by seizures evoked acutely, by 6Hz stimulation (NIH ASP); Protection against audiogenic seizures in Fring’s mice (NIH ASP). In vitro models of seizure induction: 2DG reduces epileptic discharges evoked by: potassium (7.5mM, ictal & interictal), bicuculline (GABA antagonist), 4AP (potassium channel antagonist), DHPG (metabotrophic glutamate agonist) (Stafstrom et al, 2009, UW Madison). |
| preclin tox | PET imaging agent for 30+ years; Favorable toxicity history: Completed Phase 1 in cancer, More than 20 other investigator clinical studies with > 300 subjects, Need to confirm safety in effective dose (ED) range – cardiac toxicity observed at high doses 10X > ED range, and very mild cardiac autophagy in ED range. |
| Phase 1 | |
| Phase 2 | |
| Phase 3 | |
| Adverse effects | |
| publications | |
| IP | Exclusive license from WARF for all human therapeutic use: 1 patent issued and 1 pending in US (has been issued in Australia |
| Potential problems | |
| Timeline | Complete preclinical toxicity, formulation, CMC, and filing of IND [IND-enabling preclinical studies supported by NIH RAID, may be underway Q2 2010]. Will complete preclinical studies including bioanalytical assay development, pharmacokinetic, toxicological, toxicokinetic, manufacturing, formulation, and clinical trial designs, and regulatory documentation for submission of an IND. Investigator-initiated first in humans Phase I/II clinical trial in patients with intractable epilepsy (pilot study to detect an efficacy signal and assess tolerability in 10-15 patients with frequent seizures; to start 4th q 2010 Development of delayed release formulations: to exploit the activity-dependent uptake and short t1/2 (~ 40 min) enabling chronic administration at lower total doses. |
| Financial Status | Wisconsin Alumni Research Fund (WARF) |
| Partnerships | |
| ETP Support | Grant |
| Title | Posted | |
|---|---|---|
| Nocturnal seizures | May 25, 2012 | |
| nocturnal11 | ||
| Lamictal & Seizure questions - help??? | May 25, 2012 | |
| PPlex | ||
| Severe Epilepsy And Pregnancy | May 25, 2012 | |
| AmyBoop88 | ||
| 7 yr old seizures and autism/hearing loss/adhd, etc | May 25, 2012 | |
| jackjack | ||
| epilepsy and hormonal effects | May 25, 2012 | |
| cindyloowho | ||
| Tried Potiga yet? | May 24, 2012 | |
| tcameron | ||
| Can exercise induce seizures? | May 24, 2012 | |
| MichaelK | ||
| Lamictal Nausea, Dizzy Spells | May 24, 2012 | |
| karyliin6 | ||
| Anyone on Lamictal AND Keppra? | May 24, 2012 | |
| Bloodyrose | ||
| Paying for your seizure pills with no insurance? | May 24, 2012 | |
| Tatianalee | ||
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| Title | Posted | |
|---|---|---|
| Update 2012 -- lots has happened! | May 25, 2012 | |
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| Title | Posted | |
|---|---|---|
| Angela-48 | May 11, 2012 | |
| ANGELA-48 | ||
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| mytboy | ||
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| Title | Posted | |
|---|---|---|
| Imagining the past | May 25, 2012 | |
| jrgeorge | ||
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