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Mechanisms of action of zonisamide: Professional

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New comprehensive downloadable medication sheet
  • Additional information on this drug and how to use it.
  • A starting point for discussion with your doctor.
  • Answers to frequently asked questions.

Zonisamide is chemically classified as a sulfonamide. It is not chemically related to any other seizure medicines.

The primary mechanisms of action of zonisamide appear related to blockage of voltage-dependent sodium and T-type (but not L-type) calcium channels. Zonisamide is a less potent carbonic anhydrase inhibitor than acetazolamide and therefore this effect is probably not a major contributor to its mechanism of action. Zonisamide is a broad-spectrum anti-epileptic drug (AED) in animal models.


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