Effects of Zonegran (zonisamide) on other drugs Zonegran has no appreciable effect on the steady state plasma concentrations of other AEDs.

Effects of other drugs on Zonegran (zonisamide)
In the presence of enzyme-inducing AEDs, Zonegran half-life decreases by approximately 50% and plasma concentration at steady state decreases.

Zonegran is not affected by cimetidine.

AED Interaction Sheets:
Seizure drugs are often affected by drug-drug interactions. Print these informative sheets for practical help.

• Interaction sheet for zonisamide (Zonegran)