New - Progress
 Loading
|
Take control of your epilepsy and seizures. Seizure management has never been easier.
TAKE CONTROL TODAYCarbamazepine is metabolized and eliminated by the liver. It is metabolized by the hepatic P450 system (in particular, the 3A4 isoenzyme). Carbamazepine is ~70-80% protein-bound.
Carbamazepine induces its own metabolism (autoinduction) within the first month of treatment and also accelerates the metabolism of other hepatically metabolized drugs (see Interactions of Tegretol-XR with other drugs). The half-life in chronic therapy (that is, after autoinduction is complete) is 10-20 hours in young adults but is shorter in children and longer in the elderly.
The main metabolite of carbamazepine is carbamazepine-10,11-epoxide. This metabolite is active and also is associated with neurotoxicity.
Welcome to the Wiki. This space is created for epilepsy.com members to share their own experiences and expertise to help refine and expand the discussion around important topics.
No members have yet contributed to this topic. If you are not yet an epilepsy.com member, register today to get started on this Wiki topic and the many other advantages of being a member. If you are a member and wish to be the first to edit this Wiki topic, please make sure to login, then click on the orange "Start Wiki" button at the top of this page. Or, learn more about Wikis.
 zachsm... |
 Cooper... New - Can anone tell me more about absence seizures?
Created by Cooper...at1/20/09 - 6:19 pm|3 Comments Posted To: |
 boosmomma |
Lemondrop |
4Jordie My child was diagnoised with Occipital Epilepsy
Created by 4Jordieat9/22/08 - 12:20 pm|13 Comments Posted To: |
emirahs |
 onemarvy |
onemarvy |
 nytasha New - Depakote, Behaviors, and personality
Created by nytashaat2/11/08 - 4:22 pm|34 Comments Posted To: |