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Thu, 5/24/2012

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Interactions with other medications

Topics List
New comprehensive downloadable medication sheet
  • Additional information on this drug and how to use it.
  • A starting point for discussion with your doctor.
  • Answers to frequently asked questions.

Effects of phenobarbital on other drugs
Because phenobarbital accelerates hepatic metabolism, it will increase the clearance of:

  • oral contraceptives
  • valproate
  • phenytoin
  • primidone
  • carbamazepine
  • topiramate
  • lamotrigine
  • tiagabine
  • zonisamide
  • theophylline
  • warfarin
  • steroids

Effects of other drugs on Phenobarbital
Valproate will increase the serum concentration of phenobarbital by inhibiting its hepatic metabolism.

On the other hand, drugs that accelerate hepatic metabolism will lower serum concentrations of phenobarbital. These include:

  • phenytoin
  • carbamazepine
  • primidone
  • oxcarbazepine
  • felbamate

AED Interaction Sheets:
Seizure drugs are often affected by drug-drug interactions. Print these informative sheets for practical help.


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