Effects of other drugs on oxcarbazepine
The metabolism of oxcarbazepine and MHD is unaffected by induction or inhibition of the cytochrome P450 system. This reduces the potential for interactions with AEDs and other drugs that inhibit the metabolism of carbamazepine, such as erythromycin, cimetidine, and propoxyphene.

Effects of oxcarbazepine on other drugs
Studies in non-epileptic women taking oral contraceptives found that oxcarbazepine reduced ethinylestradiol and levonorgestrel concentrations. It may therefore reduce the potency of oral contraceptives and other hormonal forms of birth control.

Oxcarbazepine can inhibit the hepatic isoenzyme CYP 2C19 and thereby increase phenytoin concentrations by up to 40%.

AED Interaction Sheets:
Seizure drugs are often affected by drug-drug interactions. Print these informative sheets for practical help.

• Interaction sheet for oxcarbazepine

Reviewed by Steven C. Schachter, MD
Submitted: 01/03/08