The starting dose for children is usually 8 to 10 mg/kg per day, divided into two doses. Children under 8 may need a higher dose relative to weight than older children. Dosage increases should be done slowly to minimize side effects, with a target dose of 10-50 mg/kg per day.

The concentrations of the active metabolite, MHD, in children aged 6 to 18 are similar to those observed in adults, but those reported in children aged 2 to 5 are lower due to faster clearance.

Reviewed by Steven C. Schachter, MD
Submitted: 01/03/08