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Thu, 5/24/2012

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Clinical pharmacology of Mysoline: Advanced

Topics List
New comprehensive downloadable medication sheet
  • Additional information on this drug and how to use it.
  • A starting point for discussion with your doctor.
  • Answers to frequently asked questions.

Mysoline is metabolized in the liver to phenobarbital and another active compound, phenylethylmalonamide. It is metabolized by the hepatic P450 system. Mysoline is ~70-80% protein-bound.

Mysoline is rapidly and nearly completely absorbed following oral administration. Peak serum concentrations are reached in approximately 3 hours. When taken as monotherapy, the half-life of Mysoline is approximately 12 hours. When taken in combination with hepatic enzyme-inducing antiepileptic drugs, the half-life of Mysoline is reduced by nearly 50%.


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