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TAKE CONTROL TODAYAbsorption
Lamictal is quickly and totally absorbed when given orally, and plasma concentrations have an apparent linear relationship to dose.
Distribution and metabolism
The drug is approximately 55% bound to plasma proteins. The liver metabolizes Lamictal to inactive glucuronide conjugates that are excreted in the urine.
The half-life of Lamictal taken alone is about 25 hours, but it rises to 70 hours in patients also taking valproate. In patients also taking hepatic enzyme–inducing AEDs, the half-life of Lamictal drops to 14 hours.
Steady state
Steady state is reached after 3 to 15 days, depending on whether Lamictal is taken with enzyme-inducing AEDs, valproate, or neither.
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Switching to Lamictal + Carbatrol from generic carbamazepine
Created by at1/12/08 - 8:52 am|2 Comments |
