Older people metabolize valproate more slowly than younger adults and they are often more susceptible to side effects. Lower initial doses and caution in titration are required. A total daily dose of 5-10 mg/kg per day is appropriate for many elderly patients.

Reduced elimination extends the half-life of valproate for elderly patients, so that many need to take Depakote only once a day.

Side effects such as sleepiness, depression, or weight gain may exacerbate pre-existing problems of seniors, and their greater risk of injury from falls or other accidents makes this an area of concern. Tremor is a common side effect of Depakote and is sometimes mistaken for a parkinsonian tremor. Other antiepileptic drugs may be preferable for patients with Parkinson's disease.

Interactions with other medications are less common with Depakote than with some other antiepileptic drugs but still may be a concern. Changes in dosages of both medications are often required.