Depakene is the brand name used in the United States and Canada for valproic acid. The brand name in the UK is Convulex. Brand names used in other countries include Depakine, Orfiril, Valporal, and Valprosid.

Valproic acid dissociates to the valproate ion in the gastrointestinal tract, so its effects are virtually identical to those of other forms of valproate. These include oral divalproex sodium (Depakote or Depakote ER in the United States) and sodium valproate (Epilim in the UK and Australia), as well as an injectable solution of valproate sodium (Depacon).

Depakene became available in the 1970s, but some people found that it caused stomach upset. This problem was lessened with the introduction of slower-dissolving Depakote in 1983. There is little difference between Depakote and Depakene other than the way they are taken and how quickly they are absorbed.

Forms of Depakene
In the United States, Depakene is marketed (but seldom promoted) by Abbott Laboratories. The name or appearance may differ in other places. These descriptions apply to the U.S. versions:

Capsules

250-mg (orange-color, soft) Gelatin capsules marked with the word DEPAKENE

Syrup
250 mg per 5 mL(red liquid)

Generic formulations of valproic acid are available from several manufacturers in the same forms: 250-mg capsules and a syrup of 250 mg/5 mL.

How to take and store Depakene
Depakene capsules must be swallowed whole. Chewing could result in local irritation of the mouth and throat. They are best taken on a full stomach to avoid stomach upset, but they can be taken without food. Advise patients that if they take the capsule alone, they should be sure to drink a full glass of water.

Depakene syrup can be mixed with another liquid or food for better taste, as long as it is all consumed. Instruct patients to use a standard measuring spoon or dropper for correct, consistent dosing.

Both capsules and syrup should be stored at room temperature, away from heat, light, and dampness. Don't let the syrup become frozen.

Missed doses
In general, tell patients that if they forget a dose, they should take it as soon as they remember. If it is almost time for the next dose, they should delay that dose for a few hours, instead of taking two doses very close together.

Patients who often forget doses may benefit from using a special pillbox or watch with an alarm. Switching to a once-a-day extended-release form (in the U.S., Depakote ER) may also help with compliance.