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Clinical pharmacology of clonazepam

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New comprehensive downloadable medication sheet
  • Additional information on this drug and how to use it.
  • A starting point for discussion with your doctor.
  • Answers to frequently asked questions.

Clonazepam is metabolized in the liver by the cytochrome P-450 system and the metabolites are excreted by the kidneys. Clonazepam is approximately 85% protein bound.

Clonazepam is rapidly and nearly completely absorbed following oral administration. Peak serum concentrations are reached in approximately 1-4 hours. The half-life of clonazepam in multiple dose studies is approximately 30-40 hours. The effects of age, gender, hepatic dysfunction and renal dysfunction on the pharmacokinetics of clonazepam have not been well studied.



Reviewed by Steven C. Schachter M.D., April 2005


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