New - Topamax Withdrawal?
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Take control of your epilepsy and seizures. Seizure management has never been easier.
TAKE CONTROL TODAYIf you visit PubMed (http://www.ncbi.nlm.nih.gov/pubmed/), a service of the National Library of Medicine, you can read summaries of studies that have tested Topamax, as well as other reports about this medication.
Here are links to some articles relevant to this subject:
Biton V, Montouris GD, Ritter F, et al. A randomized, placebo-controlled study of topiramate in primary generalized tonic-clonic seizures. Topiramate YTC Study Group. Neurology 1999 Apr 22;52(7):1330-7. PMID: 10227614.
Topamax was effective as add-on therapy for primary generalized seizures in both adults and children, and side effects were not a serious problem.
Cramer JA, Ben Menachem E, French J. Review of treatment options for refractory epilepsy: new medications and vagal nerve stimulation. Epilepsy Res 2001 Nov;47(1-2):17-25. PMID: 11673017.
In a number of research studies, Topamax was more successful than six other new seizure medicines in controlling partial seizures as add-on therapy, but it had a higher rate of unwanted side effects at high doses.
Crawford P. An audit of topiramate use in a general neurology clinic. Seizure 1998 Jun;7(3):207-11. PMID: 9700833.
Khan A, Faught E, Gilliam F, Kuzniecky R. Acute psychotic symptoms induced by topiramate. Seizure 1999 Jun;8(4):235-7. PMID: 10452922.
Mula M, Trimble MR, Lhatoo SD, Sander JW. Topiramate and psychiatric adverse events in patients with epilepsy. Epilepsia 2003 May;44(5):659-63. PMID: 12752464.
Reife RA, Pledger GW: Topiramate as adjunctive therapy in refractory partial epilepsy: pooled analysis of data from five double-blind, placebo-controlled trials. Epilepsia 38 Suppl 1: S31, 1997. PMID 9092956.
Sachdeo RC, Glauser TA, Ritter F, et al. A double-blind, randomized trial of topiramate in Lennox-Gastaut syndrome. Topiramate YL Study Group. Neurology 1999 Jun 10;52(9):1882-7. PMID: 10371538.
Trimble MR, Rusch N, Betts T, Crawford PM. Psychiatric symptoms after therapy with new antiepileptic drugs: psychopathological and seizure related variables. Seizure 2000 Jun;9(4):249-54. PMID: 10880283.
Read more about how to find and understand information in PubMed.
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