Any time a doctor suggests a new prescription, be sure to talk about what other medicines, supplements, herbs, and vitamins are already being taken. Sometimes one kind of medicine changes the way another kind of medicine works in the body. If two kinds of medicine affect each other, the doctor may prescribe something else or change the amount to be taken.

In clinical trials, Sabril lowered phenytoin (Dilantin) levels about 20%, but had little or no effect on other antiepileptic drug levels. Conversely, antiepileptic drugs have little effect on Sabril. The manufacturer’s package insert says that Sabril is unlikely to affect the efficacy of steroid oral contraceptives.

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