Lyrica at doses of 150 to 600 mg/day have been shown to be effective as add-on (adjunctive) therapy in the treatment of adults with partial seizures. Lyrica is usually started at 75 mg two times a day or 50 mg three times a day. Based on how well Lyrica is tolerated, the dose is gradually increased to a maximum dose of 600 mg/day. Doses higher than 600 mg/day have been taken, but have not been assessed by the FDA for safety and effectiveness.

People over age 65 and others with kidney dysfunction generally require a lower dosage and longer intervals between doses.

Reviewed October 2005 by Steven C. Schachter, MD, epilepsy.com Editorial Board.