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Clinical pharmacology of Keppra XR: Professional

Topics List
New comprehensive downloadable medication sheet
  • Additional information on this drug and how to use it.
  • A starting point for discussion with your doctor.
  • Answers to frequently asked questions.

The bioavailability of Keppra XR is similar to that of the immediate release Keppra tablets. Plasma half-life of Keppra XR is approximately 7 hours. 

Absorption
Keppra XR is rapidly and nearly completely absorbed after oral administration. Peak serum concentrations Keppra XR are achieved in about 4 hours. Daily doses and plasma concentrations are linearly related in doses tested up to 3,000 mg/day.

Distribution and metabolism
Keppra XR is not protein bound (<10%) and the major metabolic pathway is hydrolysis of the acetamide group to the inactive carboxylic derivative.

 


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