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How does zonisamide affect the brain?

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New comprehensive downloadable medication sheet
  • Additional information on this drug and how to use it.
  • A starting point for discussion with your doctor.
  • Answers to frequently asked questions.

Brain cells need to work (fire) at a certain rate to function normally. During a seizure, brain cells are forced to work much more rapidly than normal. Zonisamide helps prevent brain cells from working as fast as a seizure requires them to. In this way, seizures can be stopped when they are just beginning.


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