Patients with partial seizures who took Lyrica in the clinical studies and discontinued because of side effects most often mentioned:

• dizziness
• imbalance
• tiredness, sleepiness

Less common reasons for discontinuing Lyrica in the clinical studies were:

• weakness
• double or blurred vision
• trouble concentrating/thinking
• nausea
• tremor
• headache
• confusion

Other side effects that can occur when Lyrica is taken in combination with other seizure medicines include:

• accidental injury
• pain
• increased appetite
• dry mouth
• constipation
• weight gain
• swelling in the extremities (edema)
• trouble with memory
• trouble with speech
• twitching
• euphoria (feeling “high”)

If you notice problems like any of these while you are taking Lyrica, it's probably a good idea to discuss them with your doctor or nurse. Don't stop taking Lyrica or any other seizure medicine without the doctor's advice. Sometimes the doctor can help with these side effects by changing the prescription:

• reducing the overall amount
• prescribing smaller doses, to be taken more often
• changing the amount taken at certain times, such as taking a greater proportion at bedtime to reduce daytime sleepiness

Allergic reactions

There do not appear to be any allergic reactions to Lyrica.

Long-term side effects

The long-term side effects of Lyrica are not known.

Reviewed October 2005 by Steven C. Schachter, MD, epilepsy.com Editorial Board.