In clinical studies of patients with epilepsy, only 10 patients over the age of 65 took Lyrica. More patients over the 65 took Lyrica in the clinical studies for postherpetic neuralgia and painful diabetic neuropathy (see Besides epilepsy, what else is Lyrica used for?). There were no apparent differences in safety or effectiveness in patients over 65 compared to younger patients.

Still, because older people have diminished kidney function and tend in general to be more sensitive to medication side effects, it's reasonable for the doctor to prescribe a low dose at the beginning and increase it more slowly than for a younger person.

Some common side effects of Lyrica, such as trouble with coordination, may worsen pre-existing problems of seniors, and their greater risk of injury from falls or other accidents makes this an area of concern.

Because Lyrica generally does not interact with other medications, it can be a good choice for people (such as many seniors with epilepsy) who also are being treated for other disorders.

To reduce side effects, the doctor will probably prescribe a low dose of Lyrica to start and then be very cautious about any increases. It’s especially important for seniors to keep the doctor informed about any changes that they notice.

Reviewed October 2005 by Steven C. Schachter, MD, epilepsy.com Editorial Board.