Depakene (DEH-pah-keen) is a brand name used in the United States and Canada for a type of medicine called valproic (val-PRO-ik) acid. The brand name in the UK is Convulex. Brand names used in other countries include Depakine, Orfiril, Valporal, and Valprosid.

When you read about Depakene, you will also see the word valproate (val-PRO-ate). This is the name of the medicine in Depakene after it has changed into the form that actually works in the body. A few other seizure medicines also are changed into valproate, so they work in the same way as Depakene. The other valproate medicines in the United States are Depakote, Depakote ER, Depacon (given by injection), and valproic acid.

Depakene first became available in the United States in 1978, so doctors have plenty of experience in using it. It is used much less often than the slower-dissolving valproate medicine called Depakote, however.

Forms
In the United States, Depakene is sold by Abbott Laboratories. The name or appearance may be different in various countries but usually the dose (measured in milligrams, abbreviated "mg") will be the same. These descriptions apply to the U.S. versions:

250-mg (orange-color, soft) Gelatin capsules marked with the word DEPAKENE

Syrup
250 mg per 5 mL(red liquid)

Generic (non–brand name) formulations of valproic acid are available from several manufacturers in the same forms.

How to take and store Depakene
Follow the doctor's directions. Call if you have any questions. The way the medicine is taken depends, of course, on what form the doctor has prescribed.

Depakene capsules must be swallowed whole. If they're chewed, the mouth and throat may become irritated. They are best taken on a full stomach to avoid stomach upset, but they can be taken without food. (Drink a full glass of water if taking the capsule alone.) Depakene syrup can be mixed with another liquid or food for better taste, as long as it is all consumed. Be sure to use a standard measuring spoon or dropper for accurate, consistent dosing. Because food affects the way medicine is used by the body, try to be consistent day in and day out. A person who usually takes Depakene with meals should do that all the time.

Both forms of Depakene should be stored at room temperature, away from heat, light, and dampness. (Don't keep the capsules in the bathroom if it's damp there.) Protect the syrup from freezing. Be sure to keep Depakene where children can't get it.

What if I forget?
In general, if you forget a dose, take it as soon as you remember. If it is almost time for the next dose, delay that dose for a few hours, instead of taking two doses very close together. Then go back to the regular schedule. If you're not sure about what to do, call the doctor's office for more advice.

Do your best to follow the doctor's directions. The more often a medicine must be taken, the greater the chance of forgetting, and some people need to take Depakene three times every day. This can be difficult. If you forget doses often, it may be a good idea to get a special pillbox or watch with an alarm to remind you. You also might ask the doctor about Depakote ER, a type of valproate medicine that is taken only once a day.

Taking the right amount of seizure medicine on time every single day is the most important step in preventing seizures!