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Indications for phenytoin

Topics List
New comprehensive downloadable medication sheet
  • Additional information on this drug and how to use it.
  • A starting point for discussion with your doctor.
  • Answers to frequently asked questions.

Developed in 1938, phenytoin remains a first-line medication for epilepsy, due to its

  • efficacy against a range of syndromes
  • low cost
  • ease of use

Phenytoin is indicated for use as an anticonvulsant drug in people of all ages. Evidence supporting efficacy of phenytoin as an anticonvulsant was derived from active drug-controlled studies that enrolled patients with the following seizure types:

  • Partial seizures
  • Primary generalized tonic-clonic seizures (grand mal)

Phenytoin is best used for partial-onset seizures. It generally is not effective against generalized-onset absence seizures or infantile spasms.

Phenytoin has limited value in clonic, myoclonic, and atonic seizures and in the Lennox-Gastaut syndrome. It may control the tonic-clonic component of the syndrome.


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