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May 23, 2015
Winesett SP, Bessone SK, Kossoff EH
Available pharmacologic treatments for seizures are limited in their efficacy. For a patient with seizures, pharmacologic treatment with available anticonvulsant medications leads to seizure control in
May 20, 2015
Reyes G, Flesler S, Armeno M, Fortini S, Ariela A, Cresta A, Mestre G, Caraballo RH
UNLABELLED: Epileptic encephalopathy with electrical status epilepticus during slow sleep (ESES) belongs to the group of epileptic encephalopathies that often prove refractory to AED treatment. The ketogenic diet (KD) ...
May 20, 2015
Chwiej J, Skoczen A, Matusiak K, Janeczko K, Patulska A, Sandt C, Simon R, Ciarach M, Setkowicz Z
A growing body of evidence demonstrates that dietary therapies, mainly the ketogenic diet, may be highly effective in the reduction of epileptic seizures. All of them share the common characteristic of restricting carb...
May 20, 2015
Schwarzkopf TM, Koch K, Klein J
Triheptanoin, an oily substance, consists of glycerol bound to three molecules of heptanoic acid, a C7 odd-chain fatty acid. A triheptanoin-rich diet has anaplerotic effects because heptanoate metabolism yields succina...
May 16, 2015
Lima PA, Sampaio LP, Damasceno NR
A ketogenic diet is an important therapy used in the control of drug-refractory seizures. Many studies have shown that children and adolescents following ketogenic diets exhibit an over 50% reduction in seizure frequen...
May 15, 2015
Armeno M, Caraballo R, Vaccarezza M, Alberti MJ, Ríos V, Galicchio S, de Grandis ES, Mestre G, Escobal N, Matarrese P, Viollaz R, Agostinho A, Díez C, Cresta A, Cabrera A, Blanco V, Ferrero H, Gambarini V, Sosa P, Bouquet C, Caramuta L, Guisande S, Gamboni B, Hassan A, Pesce L, Argumedo L, Dlugoszewski C, DeMartini MG, Panico L
INTRODUCTION: Epilepsy is a chronic disease with onset in infancy affecting 0.5-1% of the population. One third of the patients is refractory to antiepileptic drugs and they pose a challenge for the health care team. T...
May 15, 2015
Wang KD, Cui G, Shen M
OBJECTIVE: To explore the electroencephalographic changes of patients with hyperphenylalaninemia (HPA) after dietetic treatments. METHODS: From July 2005 to February 2010, 34 HPA patients with abnormal electroe...
May 13, 2015
Masino SA, Kawamura M, Ruskin DN
Adenosine receptors are a powerful therapeutic target for regulating epileptic seizures. As a homeostatic bioenergetic network regulator, adenosine is perfectly suited to establish or restore an ongoing balance between...
May 13, 2015
Fathe K, Palacios A, Finnell RH
BACKGROUND: Valproic acid (VPA) is a commonly prescribed drug for those affected by epilepsy and bipolar disorders. VPA has a well known teratogenic potential, causing a variety of birth defects including neural tube d...
May 13, 2015
Nieoczym D, Socała K, Raszewski G, Wlaź P
Quercetin is one of the most widely occurring flavonoid which is also often present in plants as glycosidic form - rutin. These compounds are ingredients of plant diet and are also present in numerous pharmaceutical pr...