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Aug 20, 2016
Hartman AL, Santos P, O'Riordan KJ, Stafstrom CE, Hardwick JM
There are no effective treatments for millions of patients with intractable epilepsy. High-fat ketogenic diets may provide significant clinical benefit but are challenging to implement. Low carbohydrate levels appear t...
Aug 20, 2016
Fox A, Gilbert R
AIM: We report the effective use of the synthetic parathyroid hormone (PTH) teriparatide to treat a 4 year old boy with autosomal dominant hypocalcaemia. BACKGROUND: Autosomal Dominant hypocalcaemia is characte...
Aug 20, 2016
Piermartiri T, Pan H, Figueiredo TH, Marini AM
α-Linolenic acid (ALA) is a nutraceutical found in vegetable products such as flax and walnuts. The pleiotropic properties of ALA target endogenous neuroprotective and neurorestorative pathways in brain and involve the...
Aug 19, 2016
Rezende GH, Guidine PA, Medeiros Dde C, Moraes-Santos T, Mello LE, Moraes MF
Given the known effects of undernutrition over protein synthesis, we promoted neonatal undernutrition to evaluate its effect over the neuroplasticity induced by the pilocarpine model of epilepsy and also over spontaneo...
Aug 19, 2016
Sarmento Vasconcelos V, Macedo CR, de Souza Pedrosa A, Pereira Gomes Morais E, Porfírio GJ, Torloni MR
BACKGROUND: An estimated 1% to 3% of all individuals will receive a diagnosis of epilepsy during their lives, which corresponds to approximately 50 million affected people worldwide. The real prevalence is possibly hig...
Aug 19, 2016
Yum MS, Lee M, Woo DC, Kim DW, Ko TS, Velíšek L
BACKGROUND: Infantile spasms (IS) is a devastating epileptic encephalopathy. The ketogenic diet (KD) has been successfully used as a treatment for IS. This study was designed to test whether beta-hydroxybutyrate (BHB),...
Aug 19, 2016
DeGiorgio CM, Taha A
INTRODUCTION: There is growing interest in alternative and nutritional therapies for drug resistant epilepsy. ῳ-3 fatty acids as fish or krill oil are widely available supplements used to lower triglycerides and enhanc...
Aug 17, 2016
Müller A, Helbig I, Jansen C, Bast T, Guerrini R, Jähn J, Muhle H, Auvin S, Korenke GC, Philip S, Keimer R, Striano P, Wolf NI, Püst B, Thiels Ch, Fogarasi A, Waltz S, Kurlemann G, Kovacevic-Preradovic T, Ceulemans B, Schmitt B, Philippi H, Tarquinio D, Buerki S, von Stülpnagel C, Kluger G
OBJECTIVE: Mutations in the CDKL5 gene cause an early-onset epileptic encephalopathy. To date, little is known about effective antiepileptic treatment in this disorder. METHOD: Accordingly, the aim of this retr...
Aug 17, 2016
Murray AJ, Knight NS, Cole MA, Cochlin LE, Carter E, Tchabanenko K, Pichulik T, Gulston MK, Atherton HJ, Schroeder MA, Deacon RM, Kashiwaya Y, King MT, Pawlosky R, Rawlins JN, Tyler DJ, Griffin JL, Robertson J, Veech RL, Clarke K
Ketone bodies are the most energy-efficient fuel and yield more ATP per mole of substrate than pyruvate and increase the free energy released from ATP hydrolysis. Elevation of circulating ketones via high-fat, low-carb...
Aug 17, 2016
Simeone TA, Matthews SA, Samson KK, Simeone KA
The ketogenic diet (KD) is an effective therapy primarily used in pediatric patients whom are refractory to current anti-seizure medications. The mechanism of the KD is not completely understood, but is thought to invo...

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