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May 13, 2015
Masino SA, Kawamura M, Ruskin DN
Adenosine receptors are a powerful therapeutic target for regulating epileptic seizures. As a homeostatic bioenergetic network regulator, adenosine is perfectly suited to establish or restore an ongoing balance between...
May 13, 2015
Fathe K, Palacios A, Finnell RH
BACKGROUND: Valproic acid (VPA) is a commonly prescribed drug for those affected by epilepsy and bipolar disorders. VPA has a well known teratogenic potential, causing a variety of birth defects including neural tube d...
May 13, 2015
Nieoczym D, Socała K, Raszewski G, Wlaź P
Quercetin is one of the most widely occurring flavonoid which is also often present in plants as glycosidic form - rutin. These compounds are ingredients of plant diet and are also present in numerous pharmaceutical pr...
May 13, 2015
Pitchaimani V, Arumugam S, Thandavarayan RA, Karuppagounder V, Sreedhar R, Afrin R, Harima M, Suzuki H, Miyashita S, Nomoto M, Sone H, Suzuki K, Watanabe K
BAD-deficient mice and fasting have several common functional roles in seizures, beta-hydroxybutyrate (BHB) uptake in brain and alteration in counterregulatory hormonal regulation during hypoglycemia. Neuronal specific...
May 12, 2015
Suszyńska-Zajczyk J, Luczak M, Marczak L, Jakubowski H
Homocysteine (Hcy) is a risk factor for Alzheimer's disease (AD). Paraoxonase 1 (Pon1) participates in Hcy metabolism and is also linked to AD. The inactivation of the Pon1 gene in mice causes the accumulation of Hcy-t...
May 8, 2015
Drury R, Rehm A, Johal S, Nadler R
There is increasing concern that vitamin D deficiency poses a major health problem for children. Deficiency can cause hypocalcemic seizures, growth disturbances, and rickets and may influence diabetes, cardiovascular d...
May 6, 2015
Valera-Gran D, Navarrete-Muñoz EM, Vioque J
May 6, 2015
Romigi A, Placidi F, Izzi F
Apr 29, 2015
Schoeler NE, Cross JH, Drury S, Lench N, Mcmahon JM, Mackay MT, Scheffer IE, Sander JW, Sisodiya SM
AIM: We aimed to determine whether response to ketogenic dietary therapies (KDT) was due to undiagnosed glucose transporter type 1 deficiency syndrome (GLUT1-DS). METHOD: Targeted resequencing of the SLC2A1 gen...
Apr 24, 2015
Bruni O, Dosi C, Luchetti A, Della Corte M, Riccioni A, Battaglia D, Ferri R