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Jun 14, 2017
Delanty N, Cavallleri G
Traditional antiepileptic drug development approaches have yielded many important clinically valuable anti-epileptic drugs. However, the screening of promising compounds has been naturally agnostic to epilepsy etiology...
Jun 13, 2017
Lim Z, Wong K, Olson HE, Bergin AM, Downs J, Leonard H
OBJECTIVE: Pathogenic variants involving the CDKL5 gene result in a severe epileptic encephalopathy, often later presenting with features similar to Rett syndrome. Cardinal features of epilepsy in the CDKL5 disorder in...
Jun 10, 2017
Chwiej J, Patulska A, Skoczen A, Matusiak K, Janeczko K, Ciarach M, Simon R, Setkowicz Z
In this paper the influence of two different ketogenic diets (KDs) on the seizure-evoked elemental anomalies of hippocampal formation was examined. To achieve this purpose normal and pilocarpine treated rats previously...
Jun 8, 2017
Helen Cross J, Spoudeas H
Hypothalamic hamartoma may present with epilepsy, specifically gelastic or dacrystic seizures, or endocrine dysfunction, commonly precocious puberty. The epilepsy in many patients is drug resistant, and has a high asso...
Jun 8, 2017
Paleologou E, Ismayilova N, Kinali M
Mitochondrial disorders are a clinically heterogeneous group of disorders that are caused by defects in the respiratory chain, the metabolic pathway of the adenosine tri-phosphate (ATP) production system. Epilepsy is a...
Jun 7, 2017
Cailleaux A, Mahieu F, Heinrichs C, Adams B, Ismaili K, Brachet C
AIM: Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare disease characterized by a kidney disability to dilute urine and, as a result, severe recurrent hyponatremia. Due to wide variability in clinica...
Jun 6, 2017
Koppel SJ, Swerdlow RH
Neuroketotherapeutics represent a class of bioenergetic medicine therapies that feature the induction of ketosis. These therapies include medium-chain triglyceride supplements, ketone esters, fasting, strenuous exercis...
Jun 3, 2017
Uchida Y, Kato D, Toyoda T, Oomura M, Ueki Y, Ohkita K, Matsukawa N
Jun 1, 2017
Crepeau AZ, Sirven JI
Epilepsy is a common yet heterogeneous disease. As a result, management often requires complex decision making. The ultimate goal of seizure management is for the patient to have no seizures and no considerable adverse...
May 31, 2017
Simeone TA, Matthews SA, Simeone KA
OBJECTIVE: We have previously found that the transcription factor peroxisome proliferator-activated receptor γ (PPARγ) contributes to the mechanism of action of the ketogenic diet (KD), an established treatment for ped...